cas 7361-61-7, Xylazine | Articles data

Articles about 7361-61-7Total 3 be found

Chemical synthesis method of 2,6-dimethylaniline thiazine
The invention discloses a chemical synthesis method of 2,6-dimethylaniline thiazine. The method comprises the following steps: dissolving dried acetyl (2,6-dimethyl) aniline into an anhydrous solution; carrying out quantitative reaction on a mixed solution and carbon disulfide under the action of metal hydride to generate isothiocyanic acid-2,6-dimethyl phenyl ester; carrying out aminolysis on theisothiocyanic acid-2,6-dimethyl phenyl ester and 3-aminopropanol to obtain 1-(2,6-dimethyl)-phenyl-3-propanolyl thiourea after drying and purifying; and catalyzing and cyclizing with concentrated hydrochloric acid to obtain a target product 2,6-dimethylaniline thiazine. The preparation method disclosed by the invention has the advantages of easily-obtained raw materials, rigorous requirements onoperating conditions, simplicity in actual production and suitability for industrial mass production.
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Paragraph 0027-0056

(2019/01/16)

Process of preparing an isothiocyanate intermediate used in the preparation of xylazine
A process for preparing 2,6-dimethylphenylisothiocyanate comprises the steps of dissolving 2,6-dimethylaniline in carbon disulfide and ammonium hydroxide to form a dithiocarbamate salt. The salt is reacted with ethyl chloroformate to form 2,6-dimethylphenylisothiocyanate, which may thereafter be reacted with 3-amino-1-propanol and subsequently cyclized, by treating with hydrochloric acid, to form xylazine.
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(2008/06/13)

Process for the production of xylazine
In the preparation of 2,6-dimethylphenylisothiocyanate by reacting N-(2,6-dimethylphenyl)acetamide with sodium hydride in an organic solvent to form the corresponding anion of said amide, then reacting carbon disulfide with said anion to form said 2,6-dimethylphenylisothiocyanate, unexpectedly high yields are obtained by using as the organic solvent tetrahydrofuran or a mixture of N,N-dimethylacetamide and toluene. 2,6-Dimethylphenylisothiocyanate is an intermediate in the preparation of xylazine useful, for instance, as a sedative, an analgesic and muscle relaxant.
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(2008/06/13)