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BLOOM TECH Advanced API/Technology support XYLAZINE CAS 7361-61-7
Cas No: 7361-61-7
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Xylazine CAS:7361-61-7
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Xylazine
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Xylazine CAS 7361-61-7 C12H16N2S powder and crystal
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7361-61-7 Xylazine
Cas No: 7361-61-7
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7361-61-7 Usage

Description

Xylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM).1 It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals.2,3 This product is also available as an analytical reference standard (Item No. 22641).

Originator

Xylazine,Bayer

Uses

Antinociceptive;Alpha-2 adrenergic agonist

Uses

Xylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.

Manufacturing Process

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with thiophosgene, were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated hydrochloric acid and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated sodium hydroxide solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).

Therapeutic Function

Analgesic, Anesthetic

General Description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

Biochem/physiol Actions

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.
InChI:InChI=1/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

7361-61-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1720407)  Xylazine  United States Pharmacopeia (USP) Reference Standard 7361-61-7 1720407-200MG 4,647.24CNY Detail

7361-61-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine

1.2 Other means of identification

Product number -
Other names Xilazina [INN-Spanish]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7361-61-7 SDS

7361-61-7Synthetic route

1-(2,6-dimethylphenyl)-3-(3-propanol)thiourea

1-(2,6-dimethylphenyl)-3-(3-propanol)thiourea

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride In water at 80 - 95℃; Industrial scale;95%
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With acetic anhydride In tetrahydrofuran; ethanol113.8 g (84%)
tetrahydrofuran ("THF")

tetrahydrofuran ("THF")

2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In water; acetone
2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
With hydrogenchloride In water16.3 g (80%)
N-(2,6-dimethylphenyl)acetamide
2198-53-0

N-(2,6-dimethylphenyl)acetamide

xylazine
7361-61-7

xylazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; toluene / 0.5 h / Industrial scale
2: 50 - 80 °C / Industrial scale
3: hydrogenchloride / water / 80 - 95 °C / Industrial scale
View Scheme
ammonium hydroxide
1336-21-6

ammonium hydroxide

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

xylazine
7361-61-7

xylazine

isopropyl alcohol
67-63-0

isopropyl alcohol

2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

2,6-dimethylphenylisothiocyanate
19241-16-8

2,6-dimethylphenylisothiocyanate

Conditions
ConditionsYield
With carbon disulfide In propan-1-ol; water55.2%
gloutaric dichloride
2873-74-7

gloutaric dichloride

xylazine
7361-61-7

xylazine

C17H21ClN2O2S

C17H21ClN2O2S

Conditions
ConditionsYield
With triethylamine at 4℃;
benzoyl chloride
98-88-4

benzoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-benzamide
29280-54-4

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-benzamide

Conditions
ConditionsYield
With pyridine
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide
29280-56-6

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide

Conditions
ConditionsYield
With pyridine
ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

xylazine
7361-61-7

xylazine

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamide
29280-58-8

N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamide

Conditions
ConditionsYield
With pyridine
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

xylazine
7361-61-7

xylazine

A

(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester
40523-99-7

(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester

B

2-((Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester
67057-44-7

2-((Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With pyridine
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