741287-32-1

Basic information

• Product Name: tert-Butyl 3,4-diMethylpiperazine-1-carboxylate
• Synonyms: tert-Butyl 3,4-diMethylpiperazine-1-carboxylate
• CAS NO: 741287-32-1
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Mol File: 741287-32-1.mol

Chemical Properties

• Boiling Point: 266.6±33.0 °C(Predicted)
• Appearance: /
• Density: 0.993±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.39±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 3,4-diMethylpiperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3,4-diMethylpiperazine-1-carboxylate(741287-32-1)
• EPA Substance Registry System: tert-Butyl 3,4-diMethylpiperazine-1-carboxylate(741287-32-1)

Safety Data

• Hazardous Substances Data: 741287-32-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Tert-Butyl 3,4-dimethylpiperazine-1-carboxylate is used as a protecting group for amines in the synthesis of pharmaceuticals. Its ability to protect amines during chemical reactions allows for the selective formation of desired compounds, enhancing the efficiency and specificity of the synthesis process.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-Butyl 3,4-dimethylpiperazine-1-carboxylate is used for the development of new drugs and therapeutic agents. Its unique chemical properties and reactivity make it a valuable component in the design and synthesis of novel compounds with potential medicinal applications.
Used in Drug Discovery:
Tert-Butyl 3,4-dimethylpiperazine-1-carboxylate plays a role in drug discovery by contributing to the synthesis and development of new chemical entities. Its versatility as a protecting group and its potential to form peptide bonds make it a valuable tool in the creation of innovative drug candidates.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109-07-9 (RS)-2-methylpiperazine 
• 120737-59-9 3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 50-00-0 formaldehyd 

Downstream Products

• 25057-77-6 1,2-dimethylpiperazine 
• 1207455-35-3 8-(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)-9-(4-fluorophenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 

Relevant articles and documents

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

FIVE-MEMBERED HETEROCYCLIC DERIVATIVE

The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.

PYRAZOLE DERIVATIVE

Not available

BENZIMIDAZOLE QUINOLINONES AND USES THEREOF

Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.