Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides
Previously, our laboratory showed that the oxymethyl-modified coumarinic acid (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala 2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) exhibited low permeation across both the intestinal
Liederer, Bianca M.,Fuchs, Tarra,Velde, David Vander,Siahaan, Teruna J.,Borchardt, Ronald T.
p. 1261 - 1270
(2007/10/03)
Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors
We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i
Audigier,Mazarguil,Gout,Cros
p. 173 - 177
(2007/10/02)
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