- NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS
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The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I). Wherein, R= -H, 3-CH3, 4-NO2, 4-Cl, 2-CH3, 4-CH3, 4-Br, 4-F R1= -H, -4-OCH3, -4-NO2,-2-NO2, -4-Cl, -2,4,6-CH3, -4-CH3, -2-F,4-Br, -4-CF3, -4-S-CH3, -4-Cl,-3-CF3, -3-S-CH3, -3,5-CF3, -2-S-CH3, -3-CF3,-4-OCF3, -Si-(CH3)3, -Si-(C2H5)3, (CH3)2-Si- C2H5.
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Page/Page column 12; 13
(2016/06/15)
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- Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents
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A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription factors NF-κB and AP-1 mediated transcr
- Giri, Rajan S.,Thaker, Hardik M.,Giordano, Tony,Williams, Jill,Rogers, Donna,Sudersanam, Vasudevan,Vasu, Kamala K.
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body text
p. 2184 - 2189
(2009/09/30)
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- Studies in the antimicrobial activities of 1-substituted-3-formamidinothio- carbamides and 1,3-bis-(substitutedthioamido)guanidines
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The present research work has been undertaken in the synthesis of nitrogen, nitrogen and sulphur containing heteroacycles and heterocycles and to investigate their applications in medicinal, agricultural, industrial, pharmacological and biochemical facult
- Waghmare,Tayade,Shelke,Patil
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p. 819 - 821
(2007/10/03)
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- Conversion of alkylamines to thiocarbamoylguanidines
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N-Alkyl-, N,N-dialkyl- or N-unsubstituted-N'-(arylthiocarbamoyl)guanidines are prepared in very good yield from amines and 1-(N-arylthiocarbamoyl)amidino3,5 -dimethylpyrazoles.
- Francis,Deepa,Sreekala,Rajasekharan
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p. 3463 - 3470
(2007/10/03)
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