74924-95-1

Basic information

• Product Name: 1-Bromo-5-methoxynaphthalene
• Synonyms: 1-Bromo-5-methoxynaphthalene
• CAS NO: 74924-95-1
• Molecular Formula: C₁₁H₉BrO
• Molecular Weight: 237.09256
• Mol File: 74924-95-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Bromo-5-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-5-methoxynaphthalene(74924-95-1)
• EPA Substance Registry System: 1-Bromo-5-methoxynaphthalene(74924-95-1)

Safety Data

• Hazardous Substances Data: 74924-95-1(Hazardous Substances Data)

Usage

Chemical class

Aromatic compound with two fused benzene rings

Physical state

White crystalline solid

Common use

Building block for various organic molecules in organic synthesis

Structural features

Bromine atom and methoxy group attached to the naphthalene ring

Reactivity

Useful for substitution, addition, and coupling reactions

Applications

Production of pharmaceuticals, agrochemicals, and other high-value compounds

Hazardous nature

Potential for skin, eye, and respiratory system irritation

Safety precautions

Handle with care due to hazardous properties

Upstream product

• 52927-23-8 5-bromo-1-naphthol 
• 77-78-1 dimethyl sulfate 
• 3698-28-0 2-allylanisole 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 68449-30-9 5-bromo-1-tetralone 
• 345995-25-7 2,5-dibromo-3,4-dihydro-1(2H)-naphthalenone 

Downstream Products

• 51934-37-3 5-methoxy-1-naphthoic acid 
• 91270-82-5 1-(5-methoxynaphthalin)-phenylphosphinsaeureethylester 
• 91271-26-0 1-(5-methoxynaphthalin)-phenylphosphinsaeurechlorid 
• 91271-25-9 1-(5-methoxynaphthalin)-phenylphosphinsaeure 
• 95920-08-4 (5-Methoxy-1-naphthyl)phenylthiophosphinsaeure-chlorid 
• 95920-10-8 (5-Methoxy-1-naphthyl)phenylthiophosphinsaeure-cyanid 
• 91271-24-8 (5-Methoxy-1-naphthyl)(methyl)phosphinsaeure-O-(4-nitrophenyl)ester 
• 61982-86-3 1-methoxy-5-phenylnaphthalene 
• 61982-94-3 5-phenyl-1-naphthol 
• 1400967-97-6 C₁₆H₁₁⁽²⁾HO 

Relevant articles and documents

A Visible Light and Iron-mediated Carbocationic Route to Polysubstituted 1-Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes

A wide array of polysubstituted 1-bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel-Crafts alkylation, with the formation of two Csp2?Csp2 bonds in the process. This method gives easy access to 1-halonaphthalenes with substituent(s) at C-5 to C-8 that are otherwise hard to synthesize. (Figure presented.).

Indole derivatives for the treatment of depression and anxiety

The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

Benzofuran derivatives

The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

Piperidines derivatives and their use as serotonin receptor antagonists

The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

Substituted imidazol-pyridazine derivatives

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.