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6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is a fluorinated derivative of dihydroquinolinone with the molecular formula C9H7NOF, belonging to the quinoline class of compounds. It features a unique structure and fluorine substitution, making it a significant intermediate in the pharmaceutical industry for the synthesis of various drugs and biologically active compounds. Its antimicrobial and antifungal properties also contribute to its potential as a component in new antimicrobial agents.

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  • 75893-82-2 Structure
  • Basic information

    1. Product Name: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
    2. Synonyms: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE;6-FLUORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-fluoro-3,4-dihydro-2(1H)-quinolinone(SALTDATA: FREE);6-fluoro-1,2,3,4-tetrahydroquinolin-2-one;6-fluoro-3,4-dihydrocarbostyril;3,4-Dihydro-6-fluoro-2(1H)-quinolinone;6-Fluoro-2-oxo-1,2,3,4-tetrahydroquinoline;6-fluoro-3,4-dihydro-2(1H)-quinolinone
    3. CAS NO:75893-82-2
    4. Molecular Formula: C9H8FNO
    5. Molecular Weight: 165.17
    6. EINECS: 604-604-1
    7. Product Categories: N/A
    8. Mol File: 75893-82-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 323.5 °C at 760 mmHg
    3. Flash Point: 149.5 °C
    4. Appearance: /
    5. Density: 1.241 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(75893-82-2)
    11. EPA Substance Registry System: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(75893-82-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 75893-82-2(Hazardous Substances Data)

75893-82-2 Usage

Uses

Used in Pharmaceutical Industry:
6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is used as a building block for the synthesis of various drugs and biologically active compounds due to its unique structure and fluorine substitution, which can enhance the therapeutic properties of the resulting pharmaceuticals.
Used in Antimicrobial Applications:
6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is used as an antimicrobial agent for its demonstrated properties against certain microorganisms, making it a potentially valuable component in the development of new antimicrobial agents to combat resistant strains.
Used in Antifungal Applications:
6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is used as an antifungal agent, leveraging its ability to inhibit the growth of fungi, which is crucial in the development of treatments for fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 75893-82-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,9 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 75893-82:
(7*7)+(6*5)+(5*8)+(4*9)+(3*3)+(2*8)+(1*2)=182
182 % 10 = 2
So 75893-82-2 is a valid CAS Registry Number.

75893-82-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-fluoro-3,4-dihydro-1H-quinolin-2-one

1.2 Other means of identification

Product number -
Other names 6-fluoro-3,4-dihydrocarbostyril

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75893-82-2 SDS

75893-82-2Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

Au, Chi-Ming,Ling, Cho-Hon,Sun, Wenlong,Yu, Wing-Yiu

supporting information, p. 3310 - 3314 (2021/05/29)

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Compound for inhibiting EGFR kinase as well as preparation method and application thereof

-

Paragraph 0040; 0074-0076, (2021/01/12)

The invention provides a compound as shown in a general formula (I) and pharmaceutically acceptable salt thereof as well as a preparation method and application of the compound. The compound can selectively inhibit the activity of an EGFR (epidermal growt

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Shen, Sida,Picci, Cristina,Ustinova, Kseniya,Benoy, Veronick,Kutil, Zsófia,Zhang, Guiping,Tavares, Maurício T.,Pavlí?ek, Ji?í,Zimprich, Chad A.,Robers, Matthew B.,Van Den Bosch, Ludo,Ba?inka, Cyril,Langley, Brett,Kozikowski, Alan P.

, p. 4810 - 4840 (2021/05/07)

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS

-

Paragraph 0183; 0185, (2017/09/08)

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, tr

Regiodivergent access to five- and six-membered benzo-fused lactams: Ru-catalyzed olefin hydrocarbamoylation

Li, Bin,Park, Yoonsu,Chang, Sukbok

supporting information, p. 1125 - 1131 (2014/02/14)

We report herein a new strategy of the Ru-catalyzed intramolecular olefin hydrocarbamoylation for the regiodivergent synthesis of five- and six-membered benzo-fused lactams starting from N-(2-alkenylphenyl)formamides. Using a combined catalyst of Ru3

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

-

Page/Page column 140; 141, (2014/06/11)

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a Plasmodium parasite.

Novel approach to 3,4-dihydro-2(1H)-quinolinone derivatives via cyclopropane ring expansion

Tsuritani, Takayuki,Yamamoto, Yuhei,Kawasaki, Masashi,Mase, Toshiaki

supporting information; experimental part, p. 1043 - 1045 (2009/09/05)

N-(1'-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2(1H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups such as ester, nitrile, ether, and ketone group

NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS

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Page/Page column 58-59, (2009/10/21)

The present invention relates to novel M1 agonistic compounds of formula (I) and their use in the treatment of cognitive impairment associated i.a. with schizophrenia and in the treatment of other diseases mediated by the muscarinic M1 receptor.

The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3,4-dihydroquinolin-2-ones

Zhou, Wang,Zhang, Liangren,Jiao, Ning

experimental part, p. 1982 - 1987 (2009/08/07)

3,4-Dihydroquinolin-2-ones are of great importance in the areas of pharmaceuticals. However, the direct intramolecular radical cyclizations of the corresponding amide compounds favor 5-exo products 2. Reports on the radical cyclization reactions producing

TETRAHYDROQUINOLINE, INDOLINE, AND RELATED ANILINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES

-

Page/Page column 62, (2008/06/13)

The present invention relates to a compound of the formula: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, useful as modulators of 5 -HTi A receptor activity and/or serotonin reuptake. These compounds are useful in treating nervous system disorders, such as anxiety-related disorders, cognition-related disorders, depression, schizophrenia, or sexual dysfunction and related illnesses.

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