cas 7597-22-0, 2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine | Articles data ｜lookchem

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7597-22-0

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Discovery of ortho-carborane-conjugated triazines as selective topoisomerase I/II inhibitors
The cell growth inhibition profile of 2,4-(2-methyl-ortho-carboranyl)-4- (dimethylamino)-1,3,5-triazine (TAZ-6) was found to be similar to that of ICRF-193, a topoisomerase II inhibitor, as revealed by COMPARE analysis (correlation coefficient (r)≤0.724). Various mono-and di-ortho-carborane- substituted 1,3,5-triazines were synthesized based on the structure of TAZ-6 and tested for their ability to inhibit cell growth and the activities of topoisomerases I and II. Among the compounds synthesized, 3c, 4c, and 4f completely inhibited topoisomerase I activity without affecting topoisomerase II activity, whereas 3a and 3d completely inhibited topoisomerase II activity without affecting topoisomerase I activity, at 100μM.
Nakamura, Hiroyuki,Shoji, Atsushi,Takeuchi, Ayano,Ban, Hyun Seung,Lee, Jong-Dae,Yamori, Takao,Kang, Sang Ook
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p. 1430 - 1437
(2012/02/06)

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Chemical Properties

Boiling Point: 508.3 °C at 760 mmHg
Flash Point:261.2 °C
Density: 1.375 g/cm³
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Vapor Pressure: 1.88E-10mmHg at 25°C
Refractive Index: 1.579
PSA: 63.61000
LogP: 0.32820

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