2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine

Base Information

• Chemical Name: 2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine
• CAS No.: 7597-22-0
• Molecular Formula: C11H16ClN5O2
• Molecular Weight: 285.733
• Mol file: 7597-22-0.mol

Synonyms:4,4'-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine;

Chemical Property of 2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine

Chemical Property:

• Vapor Pressure: 1.88E-10mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 508.3 °C at 760 mmHg
• Flash Point: 261.2 °C
• PSA: 63.61000
• Density: 1.375 g/cm³
• LogP: 0.32820
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

≥99% ^*data from raw suppliers

2-Chloro-4,6-dimorpholino-1,3,5-triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine

There total 1 articles about 2-Chloro-4,6-dimorpholin-4-yl-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

morpholine (110-91-8,99108-56-2) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) → 2,6-Dichloro-4-morpholino-1,3,5-triazine (6601-22-5) + 2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine (7597-22-0)

Guidance literature:

In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1071/CH11295

Reference yield: 94.0%

2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine (7597-22-0) + 1,4-phenylenediamine (106-50-3) → N1-(4,6-dimorpholino-1,3,5-triazin-2-yl)benzene-1,4-diamine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.dyepig.2016.04.016

Reference yield: 88.0%

2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine (7597-22-0) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (1197159-91-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 5h; Reflux;

upstream raw materials:

morpholine

1,3,5-trichloro-2,4,6-triazine

Downstream raw materials:

2,4,6-tris(1-morpholino)-1,3,5-s-triazine

4,4’-(6-hydrazineyl-1,3,5-triazine-2,4-diyl)dimorpholine

C₁₂H₂₁N₇O₂

4,6-bis(morpholin-4-yl)-2-hydroxy-1,3,5-triazine