76006-17-2

Basic information

• Product Name: 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE
• Synonyms: 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE;4-c]pyridin-3-aMine;1H-Pyrazolo[3,4-c]pyridin-3-amine, 3-Amino-6-azaindole;3-Amino-1H-pyrazolo[3,4-c]pyridine;3-Amino-6-aza-1H-indazole;1H-Pyrazolo[3,4-c]pyridin-3-ylamine
• CAS NO: 76006-17-2
• Molecular Formula: C6H6N4
• Molecular Weight: 134.141
• Mol File: 76006-17-2.mol

Chemical Properties

• Melting Point: 213-214 °C(Solv: ethanol (64-17-5))
• Boiling Point: 433.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.480±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.83±0.40(Predicted)
• CAS DataBase Reference: 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE(76006-17-2)
• EPA Substance Registry System: 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE(76006-17-2)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 76006-17-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1H-Pyrazolo[3,4-c]pyridin-3-amine is used as a building block for the synthesis of various biologically active molecules, primarily in the development of potential therapeutic agents. Its unique structural features and synthetic versatility contribute to the creation of diverse compounds with potential medicinal properties.
Used in Material Science and Organic Chemistry:
Due to its intriguing structural features and synthetic versatility, 1H-Pyrazolo[3,4-c]pyridin-3-amine may also have applications in the field of material science and organic chemistry, where it can be utilized to explore new compounds and reactions.

Upstream product

• 78790-80-4 3-Azido-4-cyanopyridine 
• 113770-88-0 3-fluoro-4-pyridinecarbonitrile 
• 13958-99-1 3-bromopyridine-4-carboxamide 
• 13959-02-9 3-bromoisonicotinic acid 
• 13958-98-0 3-bromo-4-cyanopyridine 
• 271-47-6 1H-pyrazolo[3,4-c]pyridine 
• 76006-15-0 3-Nitro-1H-pyrazolo<3,4-c>pyridine 

Downstream Products

• 245325-34-2 3-cyano-1H-pyrazolo[3,4-c]pyridine 
• 76006-13-8 3-bromo-1H-pyrazolo[3,4-c]pyridine 

Relevant articles and documents

(AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS

The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use

The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Synthesis, reactivity and 13C-NMR of 1H-pyrazolo[3,4-c]pyridine derivatives

The synthesis of various 1H-pyrazolo [.-c.]pyridines was reported. 3- Cyano derivatives were obtained from the corresponding nitro compounds by Sandmeyer Reaction using Na3[Cu(CN)4] at pH 1. The 13C-NMR data of this series were also described.

Pyrazolopyridines. Part 5. Preparation and Reactions of Pyrazolopyridines

A series of pyrazolopyridines has been prepared by nitrosation of 3-acetamido-4-methylpyridines and subsequent rearrangement and cyclisation of the N-acetyl-N-nitroso-compounds produced.The reactions of the pyrazolopyridines have been investigated. 1- and 2-Acetyl and 1- and 2-benzyl compounds were obtained and their structures elucidated spectroscopically.The ring system readily undergoes electrophilic substitution in the 3-position. 7-Chloropyrazolopyridine has been shown to be more susceptible to nucleophilic substitution than the isomeric 5-chloro-compound.