Synthesis an Biological Effects of Novel Thiocolchicines. 3. Evaluation of N-Acyldeacetylthiocolchicines, N-(Alkoxycarbonyl)deacetylthiocolchicines, and O-Ethyldemethylthiocolchicines. New Synthesis of Thiodemecolcine and Antileukemic Effects of 2-Demethy
Novel and known analogues of thiocolchicine were evaluated in a tubulin binding assay in vivo in mice for acute toxicity and in the P338 lymphocytic leukemia assay.This evaluation included N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl)deacetylthiocolch
Kerekes, Peter,Sharma, Padam N.,Brossi, Arnold,Chignell, Colin F.,Quinn, Frank R.
p. 1204 - 1208
(2007/10/02)
Quantitative Structure-Activity Relationships of Colchicines against P388 Leukemia in Mice
A quantitative structure-activity relationship (QSAR) was derived for colchicine and 14 analogues acting against P388 lymphocytic leukemia in mice.Twelve additional compounds were synthesized to reinforce and confirm the correlation.The final correlation
Quinn, Frank R.,Beisler, John A.
p. 251 - 256
(2007/10/02)
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