gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity
New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume
Nguyen,Niesor,Bentzen
p. 1426 - 1433
(2007/10/02)
THE REACTION OF PHOSPHITES WITH AROYLPHOSPHONATES IN THE PRESENCE OF PROTON DONORS-REVERSE NUCLEOPHILIC ADDITION TO CARBONYL GROUPS
Trimethyl phosphite attacks the carbonyl oxygen of aromatic α-ketophosphonates in the presence of proton donors such as carboxylic acids.The intermediate quasi-phosphonium salts (6) either demethylate to a diphosphorus compound (4) in the normal Arbusov manner or dealkylate to give a phosphonate (5) and trimethyl phosphate.
Griffiths, D. V.,Jamali, H. A. R.,Tebby, J. C.
p. 173 - 176
(2007/10/02)
Novel Synthetic Aspects of the Phosphonate-Phosphate-Rearrangement. II. Synthesis of Enolphosphates from 1-Oxoalkanphosphonates and Sulfur-Ylides
Acylphosphonates 1 react with Sulfur-ylides 2 to give enolphosphates 3 and phosphonophosphates 4.The product ratio of 3 and 4 is determined by the substituent R3.If R3 is not electronwithdrawing the phosphonophosphate 4 is the sole reaction product. - Keywords: Acylphosphonates, behaviour towards S-ylides; Rearrangement of α-hydroxyphosphonates
Hammerschmidt, Friedrich,Zbiral, Erich
p. 1015 - 1024
(2007/10/02)
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