76742-48-8Relevant articles and documents
Steric interference on the redox-conjugated pyrimidine ring rotation of monoand dinuclear copper complexes with (4-Methyl-2-pyrimidinyl)imine ligands
Hattori, Yohei,Nishikawa, Michihiro,Kusamoto, Tetsuro,Kume, Shoko,Nishihara, Hiroshi
, p. 1037 - 1039 (2014)
A mononuclear copper(I) complex with N-[(4-methyl-2- pyrimidinyl)methylene] -p-toluidine (1?BF4) and a dinuclear copper(I) complex with N,N'-bis[(4-methyl-2-pyrimidinyl)- methylene]-p-phenylenediamine (2?(BF4)2) were synth
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF HPK1
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Page/Page column 20; 214, (2021/01/29)
This disclosure relates to heterocyclics as inhibitors of HPK1, in particular relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising said compound that useful for treatment of HPK1 mediated diseases and conditions such as cancer. (I)
MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2
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Page/Page column 74, (2021/08/06)
The present application provides a compound of Formula: or a pharmaceutically acceptable salt thereof, wherein ring B, L1, ring A, L2, n, R1, R2, R3, R4, and X1 are as described herein. Pharmaceutical compositions comprising the compound, as well as the methods of making and using the compound, are also provided.
MAP4K1 INHIBITORS
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Page/Page column 234; 235, (2021/07/24)
One embodiment of the disclosure is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. The variables in Formula I are defined herein. Compounds of Formula I are selective MAP4K1 inhibitors, which can be used to treat a diseases or disorders in a subject that benefits from control of MAP4K1 activity.
ISOQUINOLINE COMPOUNDS AND USES THEREOF
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Paragraph 0281-0282; 0317, (2020/02/16)
Isoquinoline compounds of formula (I) variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
ISOQUINOLINE COMPOUNDS FOR THE TREATMENT OF CANCER
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Paragraph 0294, (2020/05/15)
3-Carbonylaminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylaminoisoquinoline compounds.
SMARCA INHIBITORS AND USES THEREOF
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Paragraph 00163-00164, (2020/12/30)
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are useful in treatment of cancer.
DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
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Paragraph 0909-0910, (2019/05/15)
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activa
ISOQUINOLINES AS INHIBITORS OF HPK1
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Paragraph 0427, (2018/10/21)
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
METALLO-BETA-LACTAMASE INHIBITORS
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Page/Page column 68; 69, (2017/04/04)
The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.