77004-75-2

Basic information

• Product Name: BOC-D-ASP-OTBU
• Synonyms: BOC-D-ASP-OTBU;BOC-D-ASPARTIC ACID ALPHA-T-BUTYL ESTER;BOC-D-ASPARTIC ACID-OTBU;N-ALPHA-T-BUTOXYCARBONYL-D-ASPARTIC ACID ALPHA-T-BUTYL ESTER;5-BOC-D-Asp-Ot Bu;N-[(1,1-Dimethylethoxy)carbonyl]-D-aspartic acid 1-(tert-butyl) ester;N-Boc-D-aspartic acid 1-(tert-butyl) ester;N-(tert-butoxycarbonyl)-O1-(tert-butyl)-aspartic acid
• CAS NO: 77004-75-2
• Molecular Formula: C₁₃H₂₃NO₆
• Molecular Weight: 289.32
• Mol File: 77004-75-2.mol

Chemical Properties

• Boiling Point: 429 °C at 760 mmHg
• Flash Point: 213.3 °C
• Appearance: /Solid
• Density: 1.139
• Storage Temp.: 2-8°C
• PKA: 4.13±0.19(Predicted)
• CAS DataBase Reference: BOC-D-ASP-OTBU(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-ASP-OTBU(77004-75-2)
• EPA Substance Registry System: BOC-D-ASP-OTBU(77004-75-2)

Safety Data

• Hazardous Substances Data: 77004-75-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BOC-D-ASP-OTBU is used as a synthetic intermediate for the preparation of optically pure fluoroglutamines and their 18F-labeled derivatives. These compounds serve as metabolic imaging agents for tumors, aiding in the detection and monitoring of cancerous growths.
Used in Biochemical Research:
BOC-D-ASP-OTBU is also utilized in the synthesis of 4-methoxy-7-nitroindolinyl-D-aspartate, a photolabile caged compound. BOC-D-ASP-OTBU is essential for selective activation of glutamate transporters and N-Me-D-aspartate receptors in brain tissue, which is crucial for studying the functions and interactions of these receptors in neurological research.

Upstream product

• 126181-44-0 2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester 

Downstream Products

• 123004-74-0 tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate 
• 110207-53-9 <4--3-(tert-butoxycarbonyl)propoxy>benzoyl>formic acid 
• 110207-50-6 methyl <4--3-(tert-butoxycarbonyl)propoxy>benzoyl>formate 
• 123004-79-5 D-N-(tert-butoxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine 
• 123004-75-1 D-N-(benzyloxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine 
• 110207-51-7 di-tert-butyl N-(tert-butoxycarbonyl)nocardicin D 
• 123004-80-8 (R)-2-tert-Butoxycarbonylamino-4-[4-((R)-tert-butoxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-butyric acid tert-butyl ester 
• 123004-76-2 (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester 
• 123004-77-3 (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride 
• 110269-45-9 di-tert-butyl N-(tert-butoxycarbonyl)nocardicin A 
• 1154035-28-5 C₂₄H₃₅N₅O₉S 
• 1262523-72-7 (2R,4R)-tert-butyl-2-(tert-butoxycarbonylamino)-4-fluoro-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-90-9 C₂₆H₃₉ClN₂O₁₀ 
• 1262523-79-4 C₂₄H₃₈N₂O₉ 

Relevant articles and documents

Synthesis of meta-Carboranyl-(S)-homocysteine Sulfoxide

New (S)-homocysteine derivatives containing a meta-carborane fragment were synthesized. m-Carboranyl-(S)-homocysteine sulfoxide was obtained as a mixture of diastereoisomers. The reduction of the side-chain carboxy group of N-tert-butoxycarbonyl-(S)-aspartic acid α-tert-butyl ester with sodium tetrahydridoborate was not accompanied by racemization.