774-47-0

Basic information

• Product Name: 5,6-difluoro-indoline-2,3-dione
• Synonyms: 5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione;5,6-Difluoroindole-2,3-dione;5,6-Difluoroisatine;skln-0003
• CAS NO: 774-47-0
• Molecular Formula: C₈H₃F₂NO₂
• Molecular Weight: 183.1117264
• Mol File: 774-47-0.mol

Chemical Properties

• Melting Point: 218-220℃
• Appearance: /
• Density: 1.578 g/cm³
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5,6-difluoro-indoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-difluoro-indoline-2,3-dione(774-47-0)
• EPA Substance Registry System: 5,6-difluoro-indoline-2,3-dione(774-47-0)

Safety Data

• Hazardous Substances Data: 774-47-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5,6-difluoro-indoline-2,3-dione is used as a building block in organic synthesis for its unique structure and reactivity. Its presence in the molecular framework allows for the creation of new compounds with potential applications in various industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5,6-difluoro-indoline-2,3-dione is utilized as a key intermediate in the development of pharmaceuticals. Its distinct properties make it a promising candidate for the synthesis of new drugs with improved therapeutic effects.
Used in Biological Imaging:
5,6-difluoro-indoline-2,3-dione has been studied for its potential as a fluorescent probe in biological imaging. Its fluorescent properties allow researchers to visualize and track specific biological processes, contributing to a better understanding of cellular mechanisms.
Used in Materials Science:
In materials science, 5,6-difluoro-indoline-2,3-dione is employed as a component in the development of new materials with unique properties. Its incorporation into material frameworks can lead to the creation of advanced materials with applications in various industries, such as electronics, energy, and environmental protection.
Used in Agrochemicals:
5,6-difluoro-indoline-2,3-dione also has potential applications in the agrochemical industry. As a building block, it can be used in the synthesis of new agrochemicals with improved efficacy and selectivity, contributing to more sustainable agricultural practices.

InChI:InChI=1/C8H3F2NO2/c9-4-1-3-6(2-5(4)10)11-8(13)7(3)12/h1-2H,(H,11,12,13)

Upstream product

• 370-55-8 (2E)-N-(3,4-difluorophenyl)-2-hydroxyiminoacetamide 
• 3863-11-4 3,4-difluoroaniline 
• 302-17-0 chloral hydrate 
• 507-40-4 tert-butylhypochlorite 
• 5466-06-8 3-mercaptopropionic acid ethyl ester 

Downstream Products

• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 1391858-03-9 1-benzyl-5,6-difluoroindoline-2,3-dione 

Relevant articles and documents

METHOD FOR PRODUCING ISATIN COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an isatin compound useful as raw materials for various medical and agrochemical products and dyes, in high yield, with high purity, at low cost, and by simple operation. SOLUTION: An method for producing an isatin compound includes the reaction of an isonitrosoacetanilide compound represented by formula (1) at 15-60°C with sulfuric acid of 75% or more in concentration [R is H, a halogen atom or a linear/branched/cyclic alkyl group; n is an integer of 1-4]. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response

Telomeric G-quadruplex targeting and telomere maintenance interference are emerging as attractive strategies for anticancer therapies. Here, a novel molecular scaffold is explored for telomeric G-quadruplex targeting. A series of novel schizocommunin derivatives was designed and synthesized as potential telomeric G-quadruplex ligands. The interaction of telomeric G-quadruplex DNA with the derivatives was explored by biophysical assay. The cytotoxicity of the derivatives toward cancer cell lines was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. Among the derivatives, compound 16 showed great stabilization ability toward telomeric G-quadruplex DNA and good cytotoxicity toward cancer cell lines. Further cellular experiments indicated that 16 could induce the formation of telomeric G-quadruplex in cells, triggering a DNA damage response at the telomere and causing telomere dysfunction. These effects ultimately provoked p53-mediated cell cycle arrest and apoptosis, and suppressed tumor growth in a mouse xenograft model. Our work provides a novel scaffold for the development of telomeric G-quadruplex ligands.

A Benzisoelenazolone modified pyrrole methyl ester substituted indole ketone compound and use thereof

The invention discloses a benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound and a use thereof. The invention depends on and claims the priority of a Chinese patent application 201110105248.0 submitted on April 26, 2011. Through reference, all contents of the Chinese patent application 201110105248.0 are incorporated into the invention. The benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound is shown in the general formula I. The 2-indolone compound provided by the invention has excellent antitumor activity and can be widely used for preparation of antitumor drugs.

Utilizing Solubility differences to achieve regiocontrol in the synthesis of substituted quinoline-4-carboxylic acids

A practical method for the regiocontrolled synthesis of substituted quinoline-4-carboxylic acids is described. Solubility differences between the product quinoline regioisomers enable their facile separation, thus avoiding any challenging chromatographic purifications and allowing access to highly substituted quinoline compounds in three steps from commercially available anilines.

Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof

Methods, compounds and compositions are provided form inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic mycobacterial infections in vivo using indolo[2,1-b]quinazoline-6,12-dione compounds of the formula (I): STR1 wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, and the pharmaceutically acceptable salts thereof. The methods, compounds and compositons are particularly useful for inhibiting the growth of Mycobacterium tuberculosis, and may be used alone, or in combination with other anti-Mycobacterium tuberculosis agents, such as isoniazid, rifampin, pyrazinamide, rifabutin, streptomycin and ciprofloxacin, to provide new agents for the treatment of tuberculosis, including multidrug-resistant tuberculosis (MDRTB).

Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters

Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.

Process for preparing 2-chloro-4,5-difluorobenzoic acid

This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quinoli necarboxylic acid antibacterial agents.