83506-93-8

Basic information

• Product Name: 2-Amino-4,5-difluorobenzoic acid
• Synonyms: 2-AMINO-4,5-DIFLUOROBENZOIC ACID;4,5-DIFLUOROANTHRANILIC ACID;BUTTPARK 49\07-41;4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid);2-Amino-4,5-difluorobenzoic acid,4,5-Difluoroanthranilic acid;2-Amino-4,5-difluoro;2-Carboxy-4,5-difluoroaniline, 4,5-Difluoroanthranilic acid;Benzoicacid, 2-aMino-4,5-difluoro-
• CAS NO: 83506-93-8
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• EINECS: 1533716-785-6
• Product Categories: Fluorin-contained Benzoic acid series;Fluorobenzene;heterocyclic/Aliphatic series;Benzenes;Fluorine series
• Mol File: 83506-93-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 181-185 °C
• Boiling Point: 326.8 °C at 760 mmHg
• Flash Point: 151.4 °C
• Appearance: Clear colorless to straw/Liquid
• Density: 1.536 g/cm³
• Vapor Pressure: 8.56E-05mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.54±0.10(Predicted)
• BRN: 2834162
• CAS DataBase Reference: 2-Amino-4,5-difluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4,5-difluorobenzoic acid(83506-93-8)
• EPA Substance Registry System: 2-Amino-4,5-difluorobenzoic acid(83506-93-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36-26
• Safety Statements: 26-36-36/37/38
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 83506-93-8(Hazardous Substances Data)

Usage

Chemical Properties

Beige solid

InChI:InChI=1/C7H5F2NO2/c8-4-1-3(7(11)12)6(10)2-5(4)9/h1-2H,10H2,(H,11,12)

Upstream product

• 774-47-0 5,6-difluoro-1H-indole-2,3-dione 
• 83506-92-7 2-carboxamido-4,5-difluorobenzoic acid 
• 18959-30-3 4,5-difluorophthalic anhydride 
• 18959-31-4 4,5-difluorophthalic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 942-06-3 4,5-dichlorophthalic anhydride 
• 5470-11-1 hydroxylamine hydrochloride 
• 20372-63-8 4,5-difluoro-2-nitrobenzoic acid 

Downstream Products

• 351367-74-3 3-chloro-4,5-difluoroanthranilic acid 
• 628326-32-9 (2-amino-4,5-difluorophenyl)-N-[2-(4-fluorophenyl)ethyl]-carboxamide 
• 1242555-27-6 1-(2-amino-4,5-difluorophenyl)ethanone 
• 187949-57-1 (1R,2R)-7-Amino-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-6-fluoro quinazolin-4(3H)-one 
• 84339-06-0 ethyl 7,6-difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylate 
• 207346-42-7 2-amino-4,5-difluoro-benzoic acid,methyl ester 
• 97927-59-8 6,7-difluoro-2H-3,1-benzoxazine-2,4(1H)-dione 
• 60418-04-4 3-methyl-1,2-dehydrobenzene 
• 205259-37-6 6,7-difluoro-3,4-dihydroquinazolin-4-one 
• 155106-45-9 4,5-Difluoro-2-methylsulfanylthiocarbonylamino-benzoic acid 
• 1027905-92-5 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide 
• 64695-84-7 2-bromo-4,5-difluorobenzoic acid 

Relevant articles and documents

Aryne approach towards 2,3-difluoro-10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles

Reaction between 3-(2-pyridyl)-1,2,4-triazines and in situ generated 4,5-difluorobenzyne in toluene affords 2,3-difluoro-10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles. The structure of one representative compound was confirmed by X-ray diffraction analys

FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF

AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R1, R2 and R3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R1 and R2 together are alkylenedioxy;R4 and R5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.

Synthesis of 2-bromo-4,5-difluorobenzoic acid

The synthesis of 2-bromo-4,5-difluorobenzoic acid was achieved from difluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.