83506-93-8

Usage

Chemical Properties

Beige solid

InChI:InChI=1/C7H5F2NO2/c8-4-1-3(7(11)12)6(10)2-5(4)9/h1-2H,10H2,(H,11,12)

Upstream product

• 942-06-3 4,5-dichlorophthalic anhydride 
• 18959-30-3 4,5-difluorophthalic anhydride 
• 20372-63-8 4,5-difluoro-2-nitrobenzoic acid 
• 5470-11-1 hydroxylamine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 18959-31-4 4,5-difluorophthalic acid 
• 83506-92-7 2-carboxamido-4,5-difluorobenzoic acid 
• 774-47-0 5,6-difluoro-1H-indole-2,3-dione 

Downstream Products

• 1027905-92-5 2-Amino-N-[(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4,5-difluoro-benzamide 
• 60418-04-4 3-methyl-1,2-dehydrobenzene 
• 97927-59-8 6,7-difluoro-2H-3,1-benzoxazine-2,4(1H)-dione 
• 628326-32-9 (2-amino-4,5-difluorophenyl)-N-[2-(4-fluorophenyl)ethyl]-carboxamide 
• 748805-87-0 (2-amino-4,5-difluorophenyl)methanol 
• 205259-37-6 6,7-difluoro-3,4-dihydroquinazolin-4-one 
• 59-31-4 2-quinolone 
• 479089-75-3 2-amino-4,5-difluoro-N-methoxybenzamide 
• 207346-42-7 2-amino-4,5-difluoro-benzoic acid,methyl ester 
• 110877-64-0 2-chloro-4,5-difluorobenzoic acid 
• 228259-75-4 3-Trifluoromethyl-1-(2-azidomethyl-4,5-difluorophenyl)-1H-pyrazole-5-carboxylic acid 
• 1075698-26-8 2-(cyclopentylamino)-4,5-difluorobenzoic acid 
• 1414377-73-3 2-[1-(2-amino-4,5-difluorobenzoyl)-3-isopropylaziridin-2-yl]-N-(tert-butyl)-2-morpholinoacetamide 
• 1414377-74-4 C₂₂H₃₂F₂N₄O₃ 

Relevant academic research and scientific papers

Aryne approach towards 2,3-difluoro-10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles

Reaction between 3-(2-pyridyl)-1,2,4-triazines and in situ generated 4,5-difluorobenzyne in toluene affords 2,3-difluoro-10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles. The structure of one representative compound was confirmed by X-ray diffraction analys

Studies on the interactions of 5-R-3-(2-pyridyl)-1,2,4-triazines with arynes: inverse demand aza-Diels-Alder reaction versus aryne-mediated domino process

The interactions between substituted 5-R-3-(pyridyl-2)-1,2,4-triazines with in situ generated substituted aryne intermediates have been studied. The reaction afforded either inverse demand (ID) aza-Diels-Alder products or 1,2,4-triazine ring rearrangement (domino) products as major ones depending on the nature of both the substituents at the C5 position of the 1,2,4-triazine core or in the aryne moiety. The structures of the key products were confirmed based on X-ray data. Based on the density functional theoretical (DFT) studies of the Diels-Alder transition state geometries, the influence of the nature of arynes on the direction of the 1,2,4-triazine transformation has been proposed.

FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF

AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R1, R2 and R3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R1 and R2 together are alkylenedioxy;R4 and R5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.

Intermediates in the preparation of 4,5-difluoroanthranillic acid

Compounds of the formula STR1 which are intermediates in the preparation of 4,5-difluoroanthranilic acid, an intermediate itself in the synthesis of quinolone antibacterials, and methods of preparing these intermediates.

Synthesis of 2-bromo-4,5-difluorobenzoic acid

The synthesis of 2-bromo-4,5-difluorobenzoic acid was achieved from difluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.

Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters

Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.

Single pot process for making a fluoroanthranilic acid

Disclosed is a method of making ionized fluoroanthranilic acid from a fluorophthalic compound in a single pot process without isolating any intermediate product. A composition is prepared which comprises an aqueous solution of water, a fluorophthalic comp

Process for preparing 2-chloro-4,5-difluorobenzoic acid

This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quinoli necarboxylic acid antibacterial agents.

Method for the preparation of fluoroaniline

A process for the preparation of fluoroaniline compounds comprises the steps of (A) reacting an ammonium fluorophthalamate or a fluorophthalamic acid of the formula STR1 where n is 1 or 2 with an alkali or an alkali earth metal hypochlorite to form the corresponding fluoroanthranilic acid; and (B) decarboxylating the fluoroanthranilic acid by reaction with a mineral acid to form the corresponding fluoroaniline of the formula STR2 where n is as previously defined.