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3-Quinolinol, 6-Methoxy- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 77421-36-4 Structure
  • Basic information

    1. Product Name: 3-Quinolinol, 6-Methoxy-
    2. Synonyms: 3-Quinolinol, 6-Methoxy-;6-Methoxy-3-quinolinol;6-methoxyquinolin-3-ol
    3. CAS NO:77421-36-4
    4. Molecular Formula: C10H9NO2
    5. Molecular Weight: 175.18396
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 77421-36-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 351.8±22.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.258±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 7.93±0.40(Predicted)
    10. CAS DataBase Reference: 3-Quinolinol, 6-Methoxy-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Quinolinol, 6-Methoxy-(77421-36-4)
    12. EPA Substance Registry System: 3-Quinolinol, 6-Methoxy-(77421-36-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 77421-36-4(Hazardous Substances Data)

77421-36-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77421-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,2 and 1 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77421-36:
(7*7)+(6*7)+(5*4)+(4*2)+(3*1)+(2*3)+(1*6)=134
134 % 10 = 4
So 77421-36-4 is a valid CAS Registry Number.

77421-36-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methoxy-3-quinolinol

1.2 Other means of identification

Product number -
Other names 6-METHOXYQUINOLIN-3-OL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77421-36-4 SDS

77421-36-4Downstream Products

77421-36-4Relevant articles and documents

Synthetic and mechanistic studies on the azabicyclo[7.3.1]enediyne core and naphtho[2,3-h]quinoline portions of dynemicin A

Magnus, Philip,Eisenbeis, Shane A.,Fairhurst, Robin A.,Iliadis, Theodore,Magnus, Nicholas A.,Parry, David

, p. 5591 - 5605 (2007/10/03)

The synthesis of the 13-keto-10-azabicyclo[7.3.1]enediyne core structure of dynemicin A has been achieved by two routes, Schemes 4 and 6. The chemistry of the 13-keto core structure is dominated by the unusually facile bridgehead enolization. Comparison of the rates of cycloaromatization of a variety of enediynes revealed that substantial rate differences occurred even though the distance between the bonding acetylenes was virtually identical. A non-radical cycloaromatization pathway, initiated by thiol addition to the enediyne system, was discovered, and the simple core amine 26 exhibits modest in vitro and in vivo antitumor activity. Finally, two methods for the synthesis of the naphtho[2,3-h]quinoline portion of dynemicin A are described, and both these compounds also exhibit antitumor activity.

Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin

-

, (2008/06/13)

A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

Short Synthesis of the Dynemicin Core Structure: Unusual Bridgehead Enolate Raectivity

Magnus, Philip,Parry, David,Iliadis, Theodore,Eisenbeis, Shane A.,Fairhurst, Robin A.

, p. 1543 - 1544 (2007/10/02)

The dynemicin core azabicycloenediyne 2 is readily synthesized in five steps from the quinolines 9 or 13; the chemistry of the core enediyne is dominated by its ready enolization.

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