3-Quinolinol, 6-methoxy-

Base Information

• Chemical Name: 3-Quinolinol, 6-methoxy-
• CAS No.: 77421-36-4
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.18
• Mol file: 77421-36-4.mol

Synonyms:6-methoxyquinolin-3-ol;6-Methoxy-3-quinolinol;3-Quinolinol, 6-Methoxy-

Chemical Property of 3-Quinolinol, 6-methoxy-

Chemical Property:

• Boiling Point: 351.8±22.0 °C(Predicted)
• PKA: 7.93±0.40(Predicted)
• Density: 1.258±0.06 g/cm3(Predicted)

Purity/Quality:

3-HYDROXY-6-METHOXYQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinol, 6-methoxy-

There total 9 articles about 3-Quinolinol, 6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-amino-6-methoxyquinoline (29507-86-6) → 6-methoxy-3-quinolinol (77421-36-4)

Guidance literature:

With sulfuric acid; sodium nitrite;

DOI:10.1021/ja970435v

Reference yield: 95.0%

→ 6-methoxy-3-quinolinol (77421-36-4)

Guidance literature:

Reference yield:

4-methoxy-aniline (104-94-9) → 6-methoxy-3-quinolinol (77421-36-4)

Guidance literature:

Multi-step reaction with 4 steps

2: 48 percent / p-anisidine hydrochloride, PhSH / acetic acid / Heating

3: 86 percent / SnCl₂, HCl

4: 95 percent / NaNO₂, H₂SO₄

With hydrogenchloride; sulfuric acid; p-anisidine hydrochloride; thiophenol; tin(ll) chloride; sodium nitrite; In acetic acid;

DOI:10.1021/ja970435v

upstream raw materials:

3-hydroxy-6-methoxy-quinoline-4-carboxylic acid

3-hydroxy-6-methoxyquinoline-2-carboxylic acid

3-amino-6-methoxyquinoline

4-methoxy-aniline

Refernces

• 1、 -. "Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin". . . Retrieved 2008/06/13.
• 2、 Konishi, Masataka,Ohkuma, Hiroaki,Sakai, Fumihide,Tsuno, Takashi,Koshiyama, Hideo,et al.. "Structures of BBM-928 A, B, and C. Novel Antitumor Antibiotics from Actinomadura luzonensis". . p. 1241 - 1243. Retrieved 2007/10/02.