- GRANZYME B DIRECTED IMAGING AND THERAPY
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Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.
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Page/Page column 78; 81
(2019/09/04)
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- NEW COMPOUND USEFUL IN THE MANUFACTURE OF MEDICAMENTS
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The present invention relates to a compound of formula (I) as defined in the description and in the claims. The compound of formula (I) can be used in the manufacture of medicaments.
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Page/Page column 11
(2019/04/11)
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- Regioselective opening of unsymmetrical cyclic anhydrides: Synthesis of N-glycosylated isoasparagine and isoglutamine conjugates
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N-Glycopeptide mimetic with N-glycosylated isoasparagine and isoglutamine conjugates were synthesized by regioselective opening of unsymmetrical cyclic anhydride derivatives of l-aspartic acid and l-glutamic acid, using per-O-acetylated β-d-glycopyranosyl amine. The α-chloro derivative gave a mixture of asparagine and isoasparagine linked glycoconjugates, whereas the trifluoroacetamide derivatives gave predominantly the isoasparagine and isoglutamine linked glycoconjugates as the product. The X-ray crystal structure of the α-chloro isoasparagine linked glycoconjugate showed unique pattern of hydrogen bonding. This journal is the Partner Organisations 2014.
- Sahoo, Laxminarayan,Singhamahapatra, Anadi,Ramkumar, Vankatachalam,Loganathan, Duraikkannu
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p. 22042 - 22047
(2014/06/23)
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- Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction
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A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.
- Barclay, Fiona,Chrystal, Ewan,Gani, David
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p. 683 - 689
(2007/10/03)
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- Synthesis of L-Glutamic Acid Labelled Stereospecifically at C-3 with Deuterium and Non-stereospecifically at C-4 with Tritium
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(2S,3S)-1>-, (2S,3R)-2>-, (2S,3S,4RS)-1,4-3H1>-, and (2S,3R,4RS)-2,4-3H1>-Glutamic acid have been synthesised from the corresponding labelled aspartic acids.The route involves a step where Wolff rearrangement occurs with retention of stereochemistry at a primary migrating chiral centre.The stereochemistry at C-3 of the glutamic acids has been verified by degradation to the corresponding stereospecifically labelled 1>succinic acids.
- Field, Steven J.,Young, Douglas W.
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p. 2387 - 2392
(2007/10/02)
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