- Unambiguous characterization of the sesquiterpene (7R,9E)-1,2,11- trihydroxy-1,3,5,9-bisabolatetraene through its enantioselective synthesis
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The bisabolane sesquiterpene (7R,9E)-1,2,11-trihydroxy-1,3,5,9- bisabolatetraene previously extracted from Commiphora kua resins was prepared by enantioselective synthesis using an enzyme-mediated resolution procedure as the key step. Both the chemical st
- Serra, Stefano,Fronza, Giovanni
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supporting information; experimental part
p. 4838 - 4843
(2012/10/08)
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- Synthesis of the Bacterial Coenzyme Methoxatin
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The details of a total synthesis of methoxatin (1), the coenzyme of several bacterial alcohol dehydrogenases, are presented.Methoxatin has been prepared in 13 steps by starting from 2,3-dimethoxytoluene.The successful synthetic strategy for construction of the coenzyme used a Pfitzinger synthesis for preparation of the quinoline dicarboxylic acid portion of 1 and an "umpolung" variation of the Reissert indole synthesis for annulation of the remaining pyrrole ring.
- Gainor, James A.,Weinreb, Steven M.
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p. 2833 - 2837
(2007/10/02)
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- Total Synthesis of Methoxatin, the Coenzyme of Methanol Dehydrogenase and Glucose Dehydrogenase
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The first total synthesis of the bacterial coenzyme methoxatin has been successfully completed starting from readily available 2,3-dimethoxytoluene.
- Gainor, James A.,Weinreb, Steven M.
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p. 4317 - 4319
(2007/10/02)
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- Preparation and Catalytic Hydrogenation of 4,6-Dimethyl- and 4,7-Dimethyl-8-methoxycoumarins. A 4-Methyldihydrocoumarin Synthesis
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Reduction of the title coumarins at 1500 psi and 150 deg over 10percent palladium on charcoal provides a simple route to dihydrocoumarins and/or ethylbutanoates, hydrogenolysis products of the lactone.Lower pressures and temperatures tend to yield only th
- Mills, Frank D.
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p. 1597 - 1600
(2007/10/02)
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