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(trans)-4-PPC, also known as trans-4-phenyl-4-Piperidinocyclohexanol, is an arylcyclohexylamine that serves as a metabolite of phencyclidine (PCP). It is an analytical reference standard with the item number 20565. (trans)-4-PPC is known for its ability to inhibit dopamine uptake in rat striatal synaptosomes, similar to PCP. (trans)-4-PPC is primarily intended for research and forensic applications.

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  • 78165-07-8 Structure
  • Basic information

    1. Product Name: (trans)-4-PPC
    2. Synonyms: (trans)-4-PPC;rac trans-4'-Hydroxy Phencyclidine;rac trans-4-Phenyl-4-(1-piperidinyl)cyclohexanol;trans-1-(1-Phenyl-4-hydroxycyclohexyl)piperidine;trans-4-Phenyl-4-piperidinocyclohexanol;KPRUAZBLIREHPD-QAQDUYKDSA-N
    3. CAS NO:78165-07-8
    4. Molecular Formula: C17H25NO
    5. Molecular Weight: 259.3865
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
    8. Mol File: 78165-07-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (trans)-4-PPC(CAS DataBase Reference)
    10. NIST Chemistry Reference: (trans)-4-PPC(78165-07-8)
    11. EPA Substance Registry System: (trans)-4-PPC(78165-07-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 78165-07-8(Hazardous Substances Data)

78165-07-8 Usage

Uses

Used in Research Applications:
(trans)-4-PPC is used as a research compound for studying its effects on dopamine uptake and its potential involvement in psychotomimetic effects of PCP. It is particularly useful in understanding the mechanisms of action and the neurological impacts of phencyclidine and its metabolites.
Used in Forensic Applications:
In forensic science, (trans)-4-PPC is utilized as a reference standard for the identification and analysis of this metabolite in biological samples. This aids in the investigation of cases involving phencyclidine abuse or intoxication, as well as in toxicological assessments.
Used in Pharmaceutical Research:
(trans)-4-PPC may also be employed in the development of new pharmaceuticals targeting the dopamine system. Its inhibitory effect on dopamine uptake could be leveraged in the design of drugs for the treatment of neurological disorders associated with dopamine dysregulation, such as schizophrenia or Parkinson's disease.

Check Digit Verification of cas no

The CAS Registry Mumber 78165-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,1,6 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78165-07:
(7*7)+(6*8)+(5*1)+(4*6)+(3*5)+(2*0)+(1*7)=148
148 % 10 = 8
So 78165-07-8 is a valid CAS Registry Number.

78165-07-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol

1.2 Other means of identification

Product number -
Other names RAC TRANS-4-PHENYL-4-(1-PIPERIDINYL)CYCLOHEXANOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78165-07-8 SDS

78165-07-8Downstream Products

78165-07-8Relevant articles and documents

Metabolism of phencyclidine by microorganisms

Hufford,Baker,Clark

, p. 155 - 158 (2007/10/02)

A number of microorganisms were screened for their ability to metabolize phencyclidine. Two microorganisms, Beauveria sulfurescens and Cunninghamella echinulata, produced hydroxylated metabolites, which were identified as 1-(1-phenylcyclohexyl)-4-hydroxypiperidine and 4-phenyl-4-piperidinocyclohexanol by high-pressure liquid chromatographic analysis.

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