(trans)-4-PPC

Base Information

• Chemical Name: (trans)-4-PPC
• CAS No.: 78165-07-8
• Molecular Formula: C17H25NO
• Molecular Weight: 259.392
• Mol file: 78165-07-8.mol

Synonyms:RAC TRANS-4-PHENYL-4-(1-PIPERIDINYL)CYCLOHEXANOL;4-phenyl-4-(1-piperidinyl)cyclohexanol;4-phenyl-4-piperidinocyclohexanol;

Chemical Property of (trans)-4-PPC

Chemical Property:

• PSA: 23.47000
• LogP: 3.24060

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

trans-4-phenyl-4-Piperidinocyclohexanol ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: trans-4-phenyl-4-Piperidinocyclohexanol (Item No. 20565) is an analytical reference standard that is structurally categorized as an arylcyclohexylamine. It is a metabolite of phencyclidine (PCP; ). trans-4-phenyl-4-Piperidinocyclohexanol inhibits dopamine uptake in rat striatal synaptosomes to a similar extent as PCP. This product is intended for research and forensic applications.
• Uses: trans-4-Phenyl-4-(1-piperidinyl)cyclohexanol [(trans)-4-PPC] is the trans-isomer of the 4-hydroxy(cyclo) metabolite of Phencyclidine (P295502). Studies show that (trans)-4-PPC elicits dose-related increases in locomotor activity and rearing in mice, and (trans)-4-PPC may also be involved in psychotomimetic effects of PCP due to its inhibitory effect on DA uptake.

Technology Process of (trans)-4-PPC

There total 7 articles about (trans)-4-PPC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phencyclidine hydrochloride (956-90-1) → 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (60232-85-1) + r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol (78165-07-8)

Guidance literature:

In water; for 312h; Title compound not separated from byproducts; Ambient temperature; Beauveria sulfurescens;

DOI:10.1002/jps.2600700210

Reference yield:

phencyclidine hydrochloride (956-90-1) → 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (60232-85-1) + r-4-phenyl-4-(1-piperidinyl)-t-cyclohexanol (78165-06-7) + r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol (78165-07-8)

Guidance literature:

In water; Ambient temperature; Cunninghamella echinulata; metabolism by microorganisms; further microbial agents;

DOI:10.1002/jps.2600700210

Reference yield:

4-hydroxycyclohexanone (13482-22-9) → r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol (78165-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 5.1 g

2: NaN₃, CCl₃COOH / CHCl₃ / 5 h / 0 °C

3: LiAlH₄ / diethyl ether / Heating

4: 1.1 g / K₂CO₃ / acetone / 96 h / Heating

With lithium aluminium tetrahydride; sodium azide; potassium carbonate; trichloroacetic acid; In diethyl ether; chloroform; acetone;

DOI:10.1021/jm00346a019

upstream raw materials:

1,5-dibromo-pentane

4-Amino-4-phenyl-cyclohexanol

phencyclidine hydrochloride

4-hydroxycyclohexanone