78279-88-6

Basic information

• Product Name: CH 141
• Synonyms: CH 141
• CAS NO: 78279-88-6
• Molecular Formula: C₁₉H₂₁N₃O
• Molecular Weight: 307.38954
• Mol File: 78279-88-6.mol

Chemical Properties

• Boiling Point: 445.5°C at 760 mmHg
• Flash Point: 223.2°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 3.94E-08mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: CH 141(CAS DataBase Reference)
• NIST Chemistry Reference: CH 141(78279-88-6)
• EPA Substance Registry System: CH 141(78279-88-6)

Safety Data

• Hazardous Substances Data: 78279-88-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H21N3O/c1-2-7-16(8-3-1)19-20-12-18(23-21-19)14-22-11-10-15-6-4-5-9-17(15)13-22/h1-9,18H,10-14H2,(H,20,21)

Upstream product

• 56493-97-1 3-phenyl-6-(toluene-4-sulfonyloxymethyl)-5,6-dihydro-2⁽⁴⁾H-[1,2,4]oxadiazine 

Downstream Products

• 98-88-4 benzoyl chloride 

Relevant articles and documents

1,2,4-Oxadiazine derivatives, process for their preparation and pharmaceutical compositions containing them

The invention concerns new compounds of the general formula (I) STR1 wherein R1 is hydrogen or phenyl optionally substituted by one or more of the following substituents: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; R2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms or phenyl, optionally substituted with one or more of the following groups: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; or R2 is a naphthyl group; R3 is alkyl having 1 to 4 carbon atoms, acyl or hydrogen; R4 hydrogen or alkyl having 1 to 4 carbon atoms; R5 is cycloalkyl having 5 to 7 carbon atoms, alkyl having 1 to 6 carbon atoms, phenyl-(C1-4 -alkyl) in which the phenyl moiety may optionally be substituted with alkoxy having 1 to 4 carbon atoms, halogen or nitro; or R4 and R5 together represent a group of the general formula (V) STR2 wherein R6 is hydrogen or alkoxy having 1 to 4 carbon atoms, m and n stand for 0, 1 or 2 and acid addition and quaternary salts thereof. The compounds of the general formula (I) are potent peripheral vasodilators and hypotensive agents. They increase the coronary blood flow and in addition to their slight antiinflammatory and diuretic acidivity possess strong antiarrhythmic properties. A process for the preparation of these compounds and pharmaceutical compositions containing them are also within the scope of the invention.