783324-18-5

Basic information

• Product Name: 4-tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin
• Synonyms: 4-tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin;4-Tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin-3-yl) phenyl)benzenesulfonamide;N-[2-(2,3-dihydro-2-oxo-3-phenyl-1H-indol-3-yl)-5-hydroxy-4-methylphenyl]-4-(1,1-dimethylethyl)Benzenesulfonamide
• CAS NO: 783324-18-5
• Molecular Formula: C31H30N2O4S
• Molecular Weight: 526.654
• Mol File: 783324-18-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin(783324-18-5)
• EPA Substance Registry System: 4-tert-butyl-N-(5-hydroxy-4-methyl-2-(2-oxo-3-phenylindolin(783324-18-5)

Safety Data

• Hazardous Substances Data: 783324-18-5(Hazardous Substances Data)

Upstream product

• 2835-95-2 amino-4 hydroxy-2 toluene 
• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 723290-46-8 4-tert-butyl-N-(3-hydroxy-4-methyl-phenyl)-benzenesulfonamide 

Relevant articles and documents

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation

Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca2+ stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca2+ stores and phosphorylation of eIF2α.