- ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF
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Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.
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Page/Page column 22; 30
(2021/06/22)
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- Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives
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A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and by reactions of bis(hydroxyphenyl)methanes with bromine. New bromophenols including 3,3′,5,5′-tetrabromo-2,2′,4,4′-tetrahydroxydiphenylmethane (10), a regioisomer of the potent antimicrobial natural product, together with known derivatives were synthesized in high yield. All of the isolated and synthesized compounds were tested for antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. The preliminary structure-activity relationship, to elucidate the essential structure requirements for antimicrobial activity, has been described. Among the isolated natural products 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane (4) was found to be the most active derivative against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. The synthetic bromophenols 3,3′-dibromo-6,6′-dihydroxydiphenylmethane (13) and 3,3′,5,5′-tetrabromo-6,6′-dihydroxydiphenylmethane (14) showed potent antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, and Salmonella typhimurium.
- Oh, Ki-Bong,Lee, Ji Hye,Chung, Soon-Chun,Shin, Jongheon,Shin, Hee Jae,Kim, Hye-Kyeong,Lee, Hyi-Seung
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p. 104 - 108
(2008/09/21)
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- Synthesis of a salbutamol dimer
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First synthesis of the diastereomeric mixture of Salbutamol dimer (2) is described. The synthesis provides access to multi-gram quantities of 2 for reference supplies and further analytical and toxicology investigations. It also confirmed the proposed str
- Haddad, Nizar,Xu, Yibo,Baron, James A.,Yee, Nathan K.
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p. 1135 - 1137
(2007/10/03)
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- Specific Complexation of Glucose with a Diphenylmethane-3,3'-diboronic Acid Derivative: Correlation between the Absolute Configuration of Mono- and Di-saccharides and the Circular Dichroic Activity of the Complex
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For the development of receptor molecules that can precisely recognize sugar molecules, we recently synthesized bis-(6-methoxyphenyl)methane-3,3'-diboric acid 2.This compound forms 1:1 complexes with mono- and di-saccharides and gives circular dichroism (
- Shiomi, Yutaka,Saisho, Miwako,Tsukagoshi, Kazuhiko,Shinkai, Seiji
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p. 2111 - 2118
(2007/10/02)
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- The Synthesis of Polyfunctional Aromatic Ring Systems. Structural Analogues of Phloroglucides, Aranciamycin, Cryptosporin and Terramycin
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The synthesis of the title compounds is described.Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.
- Hakimelahi, Gholam Hosein,Moshfegh, Ali Akbar
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p. 599 - 609
(2007/10/02)
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