79055-67-7

Basic information

• Product Name: L-AP5
• Synonyms: L-AP5;L(+)-2-AMINO-5-PHOSPHONOPENTANOIC ACID;L(+)-2-AMINO-5-PHOSPHONOVALERIC ACID;(2S)-2-Amino-5-phosphonovaleric acid;(S)-5-Phosphono-2-aminovaleric acid;L(+)-2-Amino-5-phosphonovaleric acid,95% ( >99% ee)
• CAS NO: 79055-67-7
• Molecular Formula: C5H12NO5P
• Molecular Weight: 197.13
• Product Categories: Glutamate receptor
• Mol File: 79055-67-7.mol

Chemical Properties

• Melting Point: 105°C
• Boiling Point: 482.1°C at 760 mmHg
• Flash Point: 245.4°C
• Appearance: /solid
• Vapor Pressure: 1.28E-10mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-AP5(CAS DataBase Reference)
• NIST Chemistry Reference: L-AP5(79055-67-7)
• EPA Substance Registry System: L-AP5(79055-67-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 79055-67-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-AP5 is used as a research chemical for the development of drugs targeting the NMDA receptor, which plays a crucial role in various neurological processes, including learning, memory, and synaptic plasticity. Its antagonistic action on the NMDA receptor makes it a potential candidate for the treatment of neurological disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Used in Neuroscience Research:
L-AP5 is used as a research tool in neuroscience to study the role of the NMDA receptor in synaptic transmission, neuronal excitability, and neuroprotection. It helps researchers understand the mechanisms underlying various neurological conditions and develop novel therapeutic strategies.
Used in Drug Discovery and Development:
L-AP5 is used in drug discovery and development as a lead compound for the design and synthesis of new drugs targeting the NMDA receptor. Its unique pharmacological properties make it a valuable template for the development of innovative therapeutic agents with improved efficacy and safety profiles.

Biological Activity

NMDA antagonist. Also agonist at quisqualate-sensitized AP6 site, where it is more potent than the D-isomer (D-(-)-2-Amino-5-phosphonopentanoic acid ).

InChI:InChI=1/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-2/t4-/m0/s1

Upstream product

• 1186-10-3 diethyl 3-(bromopropyl)phosphonic acid 
• 56-40-6 glycine 
• 76326-31-3 APV 
• 149917-69-1 (R)-tert-butyl 4-(3-(diethoxyphosphoryl)propyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 119878-91-0 (E)-3-(3-(diethylphosphono)prop-2-en-1-yl)-4-(tert-butoxycarbonyl)-5-phenyl-2H-1,4-oxazin-2-one 
• 118492-04-9 (-)-(2R,3E)-2-amino-5-phosphono-3-pentenoic acid 

Downstream Products

• 76326-31-3 APV 

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