791626-59-0

Basic information

• Product Name: 2-CHLOROQUINOLINE-6-CARBALDEHYDE
• Synonyms: 2-CHLOROQUINOLINE-6-CARBALDEHYDE;2-CHLOROQUINOLINE-6-CARBOXALDEHYDE;6-Quinolinecarboxaldehyde, 2-chloro-;2-Chloro-6-quinolinecarboxaldehyde
• CAS NO: 791626-59-0
• Molecular Formula: C₁₀H₆ClNO
• Molecular Weight: 191.61
• Mol File: 791626-59-0.mol

Chemical Properties

• Melting Point: 165-167℃
• Boiling Point: 343.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.364±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.53±0.43(Predicted)
• CAS DataBase Reference: 2-CHLOROQUINOLINE-6-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROQUINOLINE-6-CARBALDEHYDE(791626-59-0)
• EPA Substance Registry System: 2-CHLOROQUINOLINE-6-CARBALDEHYDE(791626-59-0)

Safety Data

• Hazardous Substances Data: 791626-59-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloroquinoline-6-carbaldehyde is used as a key intermediate in the synthesis of pharmaceuticals for its potential to develop antimalarial and antitumor agents. Its unique chemical structure contributes to the creation of effective drugs that target specific diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloroquinoline-6-carbaldehyde serves as a crucial component in the development of pesticides and other agrochemical products. Its incorporation enhances the effectiveness of these products in protecting crops and managing pests.
Used in Organic Synthesis:
2-Chloroquinoline-6-carbaldehyde is used as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the formation of desired products. Its presence in these reactions allows for the synthesis of a wide range of chemical compounds.
Used in Production of Fluorescent Dyes:
2-CHLOROQUINOLINE-6-CARBALDEHYDE is utilized in the production of fluorescent dyes, where its unique properties enable the creation of dyes with specific characteristics. These dyes find applications in various fields, including research, diagnostics, and imaging.
Used in Chemical Compound Production:
2-Chloroquinoline-6-carbaldehyde acts as a building block in the production of various chemical compounds, contributing to the development of new materials and substances with diverse applications across different industries.

Upstream product

• 4295-11-8 2-chloro-6-methylquinoline 
• 123637-77-4 6-bromomethyl-2-chloro-quinoline 
• 68-12-2 N,N-dimethyl-formamide 
• 1810-71-5 6-bromo-2-chloroquinoline 
• 1810-66-8 6-bromo-2-quinolone 
• 106-40-1 4-bromo-aniline 
• 327058-51-5 N-(4-bromophenyl)-(E)-3-ethoxyacrylamide 

Downstream Products

• 1001608-59-8 5-[2-(2-fluoro-phenyl)-quinolin-6-yl]-4H-thieno[3,2-b]pyrrole-2-carboxylic acid methyl ester 
• 90800-31-0 2-oxo-1,2-dihydroquinoline-6-carbaldehyde 

Relevant articles and documents

ANTIVIRAL AGENTS

Disclosed are compounds and compositions of Formula, (I) and their uses for treating Flaviviridae family virus infections.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.

Identification and specificity studies of small-molecule ligands for SH3 protein domains

The Src Homology 3 (SH3) domains are small protein-protein interaction domains that bind proline-rich sequences and mediate a wide range of cell-signaling and other important biological processes. Since deregulated signaling pathways form the basis of many human diseases, the SH3 domains have been attractive targets for novel therapeutics. High-affinity ligands for SH3 domains have been designed; however, these have all been peptide-based and no examples of entirely nonpeptide SH3 ligands have previously been reported. Using the mouse Tec Kinase SH3 domain as a model system for structure-based ligand design, we have identified several simple heterocyclic compounds that selectively bind to the Tec SH3 domain. Using a combination of nuclear magnetic resonance chemical shift perturbation, structure-activity relationships, and site-directed mutagenesis, the binding of these compounds at the proline-rich peptide-binding site has been characterized. The most potent of these, 2-aminoquinoline, bound with Kd = 125 μM and was able to compete for binding with a proline-rich peptide. Synthesis of 6-substitued-2- aminoquinolines resulted in ligands with up to 6-fold improved affinity over 2-aminoquinoline and enhanced specificity for the Tec SH3 domain. Therefore, 2-aminoquinolines may potentially be useful for the development of high affinity small molecule ligands for SH3 domains.