4295-11-8

Basic information

• Product Name: 2-CHLORO-6-METHYL-QUINOLINE
• Synonyms: 2-CHLORO-6-METHYL-QUINOLINE;AKOS 243-77;6-METHYL-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-methyl-
• CAS NO: 4295-11-8
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63
• EINECS: -0
• Mol File: 4295-11-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 111-114 °C
• Boiling Point: 286.1 °C at 760 mmHg
• Flash Point: 154.2 °C
• Appearance: /
• Density: 1.225 g/cm³
• Vapor Pressure: 0.00463mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Room temperature.
• PKA: 0.55±0.43(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-METHYL-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYL-QUINOLINE(4295-11-8)
• EPA Substance Registry System: 2-CHLORO-6-METHYL-QUINOLINE(4295-11-8)

Safety Data

• Hazardous Substances Data: 4295-11-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8ClN/c1-7-2-4-9-8(6-7)3-5-10(11)12-9/h2-6H,1H3

Upstream product

• 4053-34-3 6-methylquinolin-2(1H)-one 
• 123637-77-4 6-bromomethyl-2-chloro-quinoline 
• 109-69-3 n-Butyl chloride 
• 583-68-6 2-bromo-p-toluidine 
• 106-49-0 p-toluidine 
• 1810-66-8 6-bromo-2-quinolone 
• 1810-71-5 6-bromo-2-chloroquinoline 
• 74-88-4 methyl iodide 
• 29969-49-1 1,6-dimethyl-2(1H)-quinolinone 
• 91-62-3 6-methylquinoline 
• 6876-68-2 N-(4-methylphenyl)-3-phenyl-2-propenamide 
• 4053-42-3 6-methylquinoline-N-oxide 
• 68882-99-5 2-ethenyl-4-methylacetanilide 
• 29289-16-5 N-(2-iodo-4-methylphenyl)acetamide 

Downstream Products

• 909404-61-1 2-(3-methylphenyl)-6-methylquinoline 
• 4053-34-3 6-methylquinolin-2(1H)-one 

Relevant articles and documents

REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR

A method involving the administration of a therapeutically effective amount of a leukotriene inhibitor, a pharmaceutically acceptable salt, a pharmaceutically acceptable N-oxide, a pharmaceutically active metabolite, a pharmaceutically acceptable prodrug, or pharmaceutically acceptable solvate thereof to a human for reducing a level of pro-inflammatory HDL in the human. Various examples of leukotriene inhibitors, including 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin- 3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2, 2-dimethyl-propionic acid, are disclosed for administration for the reduction of pro-inflammatory HDL in a human. Reduction of pro-inflammatory HDL by the leukotriene inhibitor may include conversion of at least a portion of pro-inflammatory HDL to anti-inflammatory HDL.

Enantioselective Intermolecular [2 + 2] Photocycloaddition Reactions of 2(1H)-Quinolones Induced by Visible Light Irradiation

In the presence of a chiral thioxanthone catalyst (10 mol %) the title compounds underwent a clean intermolecular [2 + 2] photocycloaddition with electron-deficient olefins at λ = 419 nm. The reactions not only proceeded with excellent regio- and diastereoselectivity but also delivered the respective cyclobutane products with significant enantiomeric excess (up to 95% ee). Key to the success of the reactions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfer and high enantioface differentiation. Preliminary work indicated that solar irradiation can be used for this process and that the substrate scope can be further expanded to isoquinolones.

2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition

Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.