79352-66-2Relevant articles and documents
Synthesis of novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds
Leflemme, Nicolas,Stoit, Axel R.,Borghese, Alfio
experimental part, p. 2432 - 2435 (2012/06/01)
With the aim to enrich our 'privileged structure'-based library, novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds were prepared. The method involved a key intramolecular Heck cyclization which was successfully applied for three series of compounds.
OXAZOLE AND THIAZOLE PPAR MODULATORS
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Page/Page column 25, (2010/11/27)
The invention provides compounds (I) pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ.
COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
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Page/Page column 57, (2008/06/13)
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
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Page/Page column 44-45, (2010/11/27)
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
Novel imidazotriazinones and the use thereof
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, (2008/06/13)
Novel imidazotrizinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.
COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
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Page 70, (2010/02/07)
This invention provides compounds that possess inhibitory activity against β--adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3 ). This invention further provides pharmaceutical compositions comprising such -compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against ?-adrenergic receptors and PDE.
A modular approach to structurally diverse bidentate chelate ligands for transition metal catalysis
Kranich, Remo,Eis, Knut,Geis, Oliver,Muehle, Stefan,Bats, Jan W.,Schmalz, Hans-Guenther
, p. 2874 - 2894 (2007/10/03)
A modular approach to a new class of structurally diverse bidentate P/N, P/P, P/S, and P/Se chelate ligands has been developed. Starting from hydroquinone, various ligands were synthesized in a divergent manner via orthogonally bis-protected bromohydroqui
The Synthesis of 5-Substituted 2,3-Dihydrobenzofurans
Alabaster, Ramon J.,Cottrell, Ian F.,Marley, Hugh,Wright, Stanley H. B.
, p. 950 - 952 (2007/10/02)
The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.
A New Route to Anthraquinones
Dodsworth, David J.,Calcagno, Maria-Pia,Ehrmann, E. Ursula,Devadas, Bhatt,Sammes, Peter G.
, p. 2120 - 2124 (2007/10/02)
The lithium salts derived from position 3 of phthalides react with arynes to form adducts, which, upon aerial oxidation, produce anthraquinones in moderate to good yields.Substituted phthalides and arynes also participate in this general reaction.The addition to unsymmetrically substituted arynes shows regioselectivity, whilst the availability of a new general route to phthalides extends the scope of this reaction.