- Method for preparing 2-[2-(4-chlorphenyl)ethyl]-2-(1,1-dimethyl ethyl) ethylene oxide
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The invention relates to a method for preparing 2-[2-(4-chlorphenyl)ethyl]-2-(1,1-dimethyl ethyl) ethylene oxide. The method comprises the following steps: adding a solvent, a raw material B and alkali into a reactor, and stirring for 0.2-1 hour; dropping 1-(4-chlorphenyl)-4,4-dimethyl-3-pentanone (raw material A) to react, thereby obtaining the 2-[2-(4-chlorphenyl)ethyl]-2-(1,1-dimethyl ethyl) ethylene oxide (formula C). The structural general formula of the raw material B is as shown in the description. In the formula, X is chlorine, bromine or iodine. The raw materials are readily available, the odor is small, the toxicity of reagents and drugs used in the operating process is relatively low, the reaction condition is mild, the time is short, and the odor is smaller than that of commondimethyl sulfide. Meanwhile, when methylbenzene serves as a solvent, the cost is low, the amount of three wastes is small, the content of target products is high, and the method is very suitable for industrial production.
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Paragraph 0023-0024; 0030-0037
(2019/02/26)
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- Synthesis method for ethylene oxide derivative
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The invention discloses a synthesis method for an ethylene oxide derivative, which is an important intermediate for pesticides and medicines. The synthesis method includes the steps of performing a reaction to alkoxy phenyl sulfide (IV) with a methylation reagent at 70-90 DEG C to synthesize sulfonium salt (III); and then performing a reaction to the sulfonium salt (III) with a carbonyl compound (II) under alkali condition to generate the ethylene oxide derivative (I). In the method, sulfur ylide is synthesized by using the alkoxy phenyl sulfide, which is difficult to volatilize and is low in odor, instead of dimethyl sulfide, which is toxic and malodorous, in a conventional method, so that a problem of malodorous odor generated during production is solved from the source, and environment stress is greatly alleviated. Meanwhile, the alkoxy phenyl sulfide can be recycled, so that industrial cost is reduced and production efficiency is increased. The method is environment-friendly and high-effectively and can be used for synthesizing various ethylene oxide derivatives as pesticide and medicine intermediates.
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Paragraph 0037; 0038; 0039; 0040-0048; 0052-0078
(2018/01/11)
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