80466-56-4

Basic information

• Product Name: 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE
• Synonyms: 4(1H)-PYRIMIDINONE, 2-AMINO-6-HYDROXY-5-NITRO-;2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE;2-AMINO-5-NITRO-PYRIMIDINE-4,6-DIOL;2-AMINO-5-NITRO-3,4,5,6-TETRAHYDROPYRIMIDINE-4,6-DIONE;4(3H)-PyriMidinone, 2-aMino-6-hydroxy-5-nitro-;2-AMino-5-nitro-4,6-pyriMidinediol;2-AMino-6-hydroxy-5-nitro-4(3H)-pyriMidinone;2-Amino-4,6-dihydroxy-5-nitropyrimidine, 2-Amino-4,6-dihydroxy-5-nitro-1,3-diazine
• CAS NO: 80466-56-4
• Molecular Formula: C4H4N4O4
• Molecular Weight: 172.1
• Product Categories: Nucleotides and Nucleosides;5-FOA;Bases & Related Reagents;Nucleotides;Amines;Aromatics;Heterocycles
• Mol File: 80466-56-4.mol

Chemical Properties

• Melting Point: >400°C
• Boiling Point: 445.3oC at 760 mmHg
• Flash Point: 223.1oC
• Appearance: /
• Density: 2.3g/cm3
• Vapor Pressure: 1.52E-08mmHg at 25°C
• Refractive Index: 1.868
• Storage Temp.: Refrigerator
• Solubility: Readily Soluble in Aqueous Potassium Hydroxide
• PKA: 2.69±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE(80466-56-4)
• EPA Substance Registry System: 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE(80466-56-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 80466-56-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H4N4O4/c5-4-6-2(9)1(8(11)12)3(10)7-4/h(H4,5,6,7,9,10)

Upstream product

• 603-67-8 diethyl nitromalonate 
• 124-46-9 guanidine hydrogen carbonate 
• 56-09-7 2-aminopyrimidine-4,6-diol 
• 80466-52-0 2-amino-6-amino-5-nitropyrimidin-4(3H)-one 
• 114113-83-6 1-amino-4,4-diethoxypentan-3-ol 
• 1007-99-4 2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one 
• 56-09-7 2-amino-6-hydroxy-pyrimidin-4(3H)-one 

Downstream Products

• 40769-69-5 2,5-diamino-4,6-dihydroxypyrimidine hydrochloride 
• 51501-53-2 2-amino-4,5,6-trichloropyrimidine 

Relevant articles and documents

A 2,5-diamino -4,6-dihydroxy-pyridine synthesis method (by machine translation)

The invention relates to a method for synthesis of compound, a 2,5? Diaminotriphenylamine? 4,6? Dihydroxybenzonic pyridine synthesis method. This method, in order to c diethyl adipic acid and hydrochloric acid guanidine is raw materials, through nitration, ammoniation reduction a series of reaction 2,5? Diaminotriphenylamine? 4,6? Dihydroxybenzonic pyridine, the method the production cost is cheap, mild reaction conditions, high yield. (by machine translation)

Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution

2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis, 2-amino-4,5,6-trichloropyrimidine is obtained instead, via unusual aromatic substitution of the nitro group in 2-amino-4-hydroxy-5-nitropyrimidin-6-one by chloride. The synthesis, the reactivity of 4,5,6-trichloropyrimidine and the efficient preparation of 2-amino-4,6-dichloro-5-nitropyrimidine are presented.

Synthesis of a Naturally Occurring Dihydrohomopteridine Insect Metabolite, 6-Acetyl-2-amino-7,8-dihydro-9H-pyrimidodiazepin-4(3H)-one

The naturally occurring dihydrohomopterin derivative 6-acetyl-2-amino-7,8-dihydro-9H-pyrimidodiazepin-4(3H)-one (1) has been synthesised from 1-amino-4,4-diethoxypentan-3-ol (10) and 2-amino-6-chloro-5-nitropyrimidin-4(3H)-one (3).A novel tricyclic intermediate, 2,2a-dihydroxy-2-methyl-6-nitro-1,2,2a,3,4,5-hexahydro-1,5,8,8b-tetra-aza-acenaphthylen-7-one was isolated.

The Synthesis and Chlorination of Some Pyrimidin-4-ols Having 5-Nitrogen Functionality

Syntheses of a number of pyrimidin-4-ols having 5-nitrogen functionality are described.Phosphorus oxychloride/diethylaniline chlorination of 6-amino-2-methylthio-5-nitropyrimidin-4-ol gave the corresponding 6-chloro derivative.However, 2-amino-6-methylthi