80827-67-4

Basic information

• Product Name: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE;1-(3-Methoxypyridin-2-yl)
• CAS NO: 80827-67-4
• Molecular Formula: C₁₀H₁₅N₃O
• Molecular Weight: 193.25
• Mol File: 80827-67-4.mol

Chemical Properties

• Melting Point: 50.5-51.5 °C
• Boiling Point: 355.965°C at 760 mmHg
• Flash Point: 169.082°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.33±0.10(Predicted)
• CAS DataBase Reference: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(80827-67-4)
• EPA Substance Registry System: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(80827-67-4)

Safety Data

• Hazardous Substances Data: 80827-67-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Methoxy-pyridin-2-yl)-piperazine is used as an intermediate in the synthesis of pharmaceutical compounds for its potential role as a central nervous system depressant. Its structure allows it to modulate the activity of the nervous system, which can be beneficial in the treatment of certain conditions.
1-(3-Methoxy-pyridin-2-yl)-piperazine is also used as a serotonin receptor antagonist, leveraging its structural components to interact with and block specific serotonin receptors. This application is crucial in the development of medications targeting a range of disorders influenced by serotonin levels.
Additionally, it serves as a dopamine receptor agonist, meaning it can stimulate dopamine receptors, which is significant in the treatment of various neurological and psychiatric conditions where dopamine levels are implicated.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 1-(3-Methoxy-pyridin-2-yl)-piperazine is utilized for its potential to interact with a variety of biological targets due to the presence of the 3-methoxy-pyridin-2-yl group. This makes it a versatile compound for exploring new avenues in drug discovery and development, particularly for conditions that may benefit from modulation of these targets.

InChI:InChI=1/C10H15N3O/c1-14-9-3-2-4-12-10(9)13-7-5-11-6-8-13/h2-4,11H,5-8H2,1H3

Upstream product

• 110-85-0 piperazine 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 24100-18-3 2-bromo-3-methoxypyridine 
• 17228-64-7 6-chloro-2-methoxypyridine 
• 1260082-69-6 4-(3-methoxypyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 6636-78-8 2-chloro-3-hydroxypyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 178974-48-6 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(3-methoxy-pyridin-2-yl)-piperazin-1-yl]-2-phenyl-butan-1-one 

Relevant articles and documents

Substituted indole compound and method and use thereof

The invention provides a new indole compound, pharmaceutically acceptable salts and medicinal preparations thereof, and a use of the new indole compound in selective inhibition of 5-hydroxytryptamine reuptake and /or excitation of a 5-HT1A receptor. The invention also relates to medicinal compositions comprising the compounds, and a method for treating the central nervous system dysfunction of mammals, especially humans by using the medicinal compositions.

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

1-indolyalkyl-4-(substituted-pyridinyl)piperazines

A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as antidepressant agents.

Succinimide derivatives, and their production and use

A succinimide derivative of the formula: STR1 wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.

ANTIPSYCHOTIC CYCLIC IMIDE DERIVATIVES OF 2-(4-BUTYLPIPERAZIN-1-YL) PYRIDINES, COMPOSITIONS AND USE

Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a substituted pyridin-2-yl ring and the second substituent is a butylene chain attached to cyclic imide heterocycles such as azaspiro 4.5!decanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, or morpholine-2,6-dione. The compounds have psychotropic properties and 2-4-4-(2,4-dioxo-1-thia-3-azaspiro 4. 5!nonane-3-yl)butyl!-1-piperazinyl!-pyridine-3-carboxaldehyde is a typical embodiment having selective antipsychotic activity.

ANTIPSYCHOTIC CYCLIC IMIDE DERIVATIVES OF 2-(4-BUTYLPIPERAZIN-1-YL)PYRIDINES, COMPOSITIONS AND USE

Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a substituted pyridin-2-yl ring and the second substituent is a butylene chain attached to cyclic imide heterocycles such as azaspiro 4.5!decanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, or morpholine-2,6-dione. The compounds have psychotropic properties and 2-4-4-(2,4-dioxo-1-thia-3-azaspiro 4. 5!nonane-3-yl)butyl!-1-piperazinyl!pyridine-3-carboxaldehyde is a typical embodiment having selective antipsychotic activity.

N-[(4-[3-CYANO SUBSTITUTED PYRIDYL]PIPERAZINO)ALKYL]-AZASPIRODECANEDIONES

2-[4-[4-(7,9-Dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-1-piperazinyl] pyridi ne-3-carbonitrile, 2-[4-[4-(7,9-dioxo-8-azaspiro-[4. 5]decan-8-yl) butyl]-3-methyl-1-piperazinyl ]pyridine-3-carbonitrile and 8-[4-[4-(3-methoxy-2-pyridinyl)-1-piperazinyl]butyl]-8-azaspiro-[4.5] decane-7,9-dione are psychotropic compounds.