81167-16-0

Basic information

• Product Name: IMILOXAN HYDROCHLORIDE
• Synonyms: RS 21361;2-(1-ETHYL-2-IMIDAZOYL)METHYL-1,4-BENZODIOXAN HYDROCHLORIDE;2-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2YL)METHYL]-1-ETHYL-1H-IMIDAZOLE HYDROCHLORIDE;IMILOXAN HYDROCHLORIDE;Imiloxan;2-(1-Ethyl-2-indazoyl)methyl-1,4-benzodioxanehydrochloride;ImiloxanHCl;RS 21361 HYDROCHLORIDE
• CAS NO: 81167-16-0
• Molecular Formula: C14H17ClN2O2
• Molecular Weight: 280.75
• Mol File: 81167-16-0.mol

Chemical Properties

• Boiling Point: 411.7°Cat760mmHg
• Flash Point: 202.8°C
• Appearance: white/solid
• Density: 1.22g/cm³
• Vapor Pressure: 1.31E-06mmHg at 25°C
• Storage Temp.: Desiccate at RT
• Solubility: H2O: 30 mg/mL, soluble
• PKA: 7.24±0.31(Predicted)
• CAS DataBase Reference: IMILOXAN HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: IMILOXAN HYDROCHLORIDE(81167-16-0)
• EPA Substance Registry System: IMILOXAN HYDROCHLORIDE(81167-16-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 81167-16-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 81167-16-0 differently. You can refer to the following data:
1. Antidepressant.
2. Imiloxan Hydrochloride is an α2-?adrenoceptor antagonist.

Biological Activity

A moderately potent, but highly selective α 2 -adrenoceptor antagonist, the only reported selective antagonist at the α 2B -adrenoceptor not having potent α 1 -adrenoceptor antagonist activity.

InChI:InChI=1/C14H16N2O2.ClH/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11;/h3-8,11H,2,9-10H2,1H3;1H

Upstream product

• 75-03-6 ethyl iodide 
• 81167-19-3 2-<(1,4-benzodioxan-2-yl)methyl>imidazole hydrochloride 
• 3789-55-7 ethyl (1,4-benzodioxan-2-yl)acetimidate hydrochloride 
• 18505-91-4 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile 

Relevant articles and documents

Method for treating alcohol abuse and alcoholism

A method for decreasing appetite for alcohol in humans which comprises the steps of providing an effective dosage of an alpha-2-adrenergic antagonist to the subject.

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and platelet aggregation inhibitors

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: STR1 wherein R1, and R2 and R3 are independently selected from the group consisting of hydrogen, and alkyl (1-6C), and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are α2 blockers and thus are useful as affectors of the CNS, specifically as platelet aggregation inhibitors and as antihypertensives.

Structure-Activity Relationships for 2-Substituted Imidazoles as α2-Adrenoceptor Antagonists

Several 2-imidazoles were prepared and evaluated for their blocking activity and relative selectivity on presynaptic (α2) and postsynaptic (α1) receptors in the isolated rat vas deferens. 1-Ethyl-2-imidazole (13) was the most selective α2-adrenoceptor antagonist of the series and was for practical purposes, devoid of α1-adrenoceptor antagonist activity.The lipophilicity of 13 (log D = 2.31) indicated that it would have an excellent chance to enter the central nervous system.Compound 13 was selected for clinical evaluation as an antidepressant agent.