- Metalation reactions XIII. The reactions of electrophiles with the dilithiated species 1-(α-lithiomethyl)-2-benzene
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Direct dimetalation of 1-methyl-2-(methylthio)benzene (1) gives the dilithiated species (2) in good yield, which can be used to introduce substituents into the thiomethyl and methyl groups.Species 2 can react also with a variety of dichlorosilanes and dichlorostannanes, and with sulphur chloride, to yield derivatives of 1,3-benzothiasilin, 1,3-benzothiastannin and 1,3-benzodithiin respectively.Reaction of 2 with tetrachlorosilane yields a spirocyclic silicon compound, while reaction with benzoyl chloride yields a derivative of 1-benzothiopyran.
- Cabiddu, S.,Floris, C.,Gelli, G.,Melis, S.
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- The preparation of some thiochroman-3-ones and derivatives
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The use of 2,3-dihydrobenzothiophene-2,3-dione as a source of 2-mercaptophenylacetic acid permits a convenient preparation of 2-carboxymethylthiophenylacetic acid or derivatives.These undergo a Dieckmann cyclization to 3-acetoxybenzothiopyrans, which m
- Clark, Peter D.,McKinnon, David M.
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p. 243 - 248
(2007/10/02)
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