81976-72-9

Basic information

• Product Name: 3-benzylpiperidin-2-one
• Synonyms: 3-benzylpiperidin-2-one
• CAS NO: 81976-72-9
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 81976-72-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-benzylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzylpiperidin-2-one(81976-72-9)
• EPA Substance Registry System: 3-benzylpiperidin-2-one(81976-72-9)

Safety Data

• Hazardous Substances Data: 81976-72-9(Hazardous Substances Data)

Upstream product

• 63930-94-9 3-benzyl-3-(ethoxycarbonyl)-2-piperidinone 
• 3731-16-6 3-carboethoxy-2-pyridone 
• 5693-62-9 2,3,4,5-tetrahydro-6-methoxypyridine 
• 907561-24-4 5-benzyl-6-methoxy-2,3,4,5-tetrahydro-pyridine 
• 675-20-7 piperidin-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 13603-25-3 3-benzylpiperidine 
• 340962-91-6 4-(3-benzyl-2-oxo-piperidin-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 37129-04-7 3-benzyl-1-methylpiperidin-2-one 

Relevant articles and documents

One-pot oxidative Mannich-type reaction of lactams with alkyl malonates

One-pot substitution of a C-H bond at the position next to the nitrogen atom of lactams with alkyl malonates proceeded effectively by dehydrogenation of lactams with N-tert-butylbenzenesulfinimidoyl chloride, followed by Mannich-type addition of alkyl malonates.

An aza-enolate alkylation strategy for the synthesis of α-alkyl-δ-amino esters and α-alkyl valerolactams

Alkylation of the aza-enolate of valerolactim methyl ether with electrophiles affords α-alkyl lactims that may be hydrolysed under mild acidic conditions to afford their corresponding α-alkyl-δ-amino esters as their hydrochloride salts. Neutralisation of these salts with base results in smooth intramolecular cyclisation to afford their corresponding α-alkyl lactams in excellent yield. Georg Thieme Verlag Stuttgart.

Anticonvulsant and anxiolytic lactam and thiolactam derivatives

This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.

Piperidine derivatives

The invention provides piperidine derivatives of the general formula STR1 or an acid-addition salt or metal salt complex thereof, in which R represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, arylcarbonyl, heterocyclyl or heterocyclyloxy group; R1 represents an optionally substituted alkyl, phenyl, benzyl or cycloalkyl group; R2 represents a hydrogen atom or an optionally substituted alkyl group; one of W and X represents --CH2 --, --CH2 CH2 -- or --O--, the other of W and X being --CH2 -- or --CH2 CH2 or X represents a single chemical bond; m is 0 or 1 and n represents an integer from 0 to 3; processes for their preparation; compositions containing such compounds and their use as fungicides.