- Effect of ketene additive and Si/Al ratio on the reaction of methanol over HZSM-5 catalysts
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The influence of ketene as possible intermediate for the reaction of methanol to aromatics was investigated over HZSM-5 catalysts (Si/Al ratio of 15 and 9) using diketene-acetone (2,2,6-trimethyl-4H-1,3-dioxin-4-one) as ketene precursor under atmospheric
- Hassanpour, Javad,Zamani, Mehdi,Dabbagh, Hossein A.
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- Fused cycloalkyl amides and acids and their therapeutic applications
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The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
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- Fused cycloalkyl amides and acids and their therapeutic applications
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The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
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- Electrophilic substitution with allylic rearrangement (SE′) stereochemistry of trifluoroacetolysis of some cyclohex-2-enylmetal compounds
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A range of (4-alkylcyclohex-2-enyl)-, (5-alkylcyclohex-2-enyl)-, and (6-alkylcyclohex-2-enyl)silanes, (4-alkylcyclohex-2-enyl)-, (5-alkylcyclohex-2-enyl)-, and (6-alkylcyclohex-2-enyl)germanes, and (4-alkyl-cyclohex-2-enyl)-, (5-alkylcyclohex-2-enyl)-, and (6-alkylcyclohex-2-enyl)stannanes were cleaved to the cycloalkene (and R3MX) with trifluoroacetic acid-d in various solvents. Complete allylic rearrangement (γ-attack) was observed, and the preferred direction of delivery of the electrophile (formally D+) to the γ-carbon of the allylic triad was determined by detailed 1H, 13C, and 2H NMR analyses of the derived dibromides of the various alkyl-substituted cyclohexenes or by direct 2H NMR analysis and comparisons with 2H-substituted alkylcyclohexenes of established relative configurations. A highly preferred γ-anti mode of acidolysis is established for all systems, except for the trans-4-tert-butylcyclohex-2-enyl derivatives, such exception being ascribed to steric impedance of electrophile approach, promoting syn attack. Thus, overall, highly γ-regioselective and anti-stereoselective substitutions (SE′) are observed.
- Wickham, Geoffrey,Young, David,Kitching, William
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p. 1187 - 1195
(2008/10/08)
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- Electrophilic Substitution with Allylic Rearrangement (SE'). Anti Stereoselectivity in Trifluoroacetolysis of Some Cyclohex-2-enylsilanes, -germanes, and -stannanes
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Trifluoroacetolysis of various cyclohex-2-enylsilanes, -germanes, and -stannanes is demonstrated to be γ regiospecific and highly anti stereoselective, as predicted for a dominating LUMO-HOMO interaction in a concerted SE2'process.
- Wickham, Geoffrey,Kitching, William
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p. 612 - 614
(2007/10/02)
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