82452-98-0

Basic information

• Product Name: 3-iodo-4(1H)-Cinnolinone
• Synonyms: 3-iodo-4(1H)-Cinnolinone;3-Iodo-1H-cinnolin-4-one;3-Iodocinnolin-4(1H)-one
• CAS NO: 82452-98-0
• Molecular Formula: C₈H₅IN₂O
• Molecular Weight: 272.04257
• Mol File: 82452-98-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-iodo-4(1H)-Cinnolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-4(1H)-Cinnolinone(82452-98-0)
• EPA Substance Registry System: 3-iodo-4(1H)-Cinnolinone(82452-98-0)

Safety Data

• Hazardous Substances Data: 82452-98-0(Hazardous Substances Data)

Upstream product

• 18514-84-6 4(1H)-cinnolon 
• 335242-55-2 3-bromo-1H-cinnolin-4-one 

Downstream Products

• 82453-11-0 2-phenyl-1H-pyrrolo<3,2-c>cinnoline 
• 82453-35-8 3-phenylethynylcinnoline 
• 82453-00-7 3-iodocinnoline 
• 82453-10-9 2-phenylfuro<3,2-c>cinnoline 
• 82452-99-1 4-chloro-3-iodocinnoline 
• 82453-26-7 E-3-phenylethenyl-4(1H)cinnolinone 

Relevant articles and documents

NOVEL CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION

The present invention relates to compounds of f formula (I) as cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2 ) receptor modulators, and uses thereof f or treating diseases, conditions and/or disorders modulated by a cannabinoid receptor ( such as pain, neurodegenrative disorders, eating disorders, weight loss or control, and obesity).

SOME REACTIONS OF 3-HALOGENOCINNOLINES CATALYSED BY PALLADIUM COMPOUNDS

3-Bromo-or 3-iodo-cinnoline (and 4-substituted analogues ) are condensed with terminal alkynes in the presence of Pd and Cu compounds as catalysts to give the 3-alkynyl-derivatives.When 4-chloro- or 4-phenoxy-compounds are used, the products react with amines, in the presence of copper(I) iodide, to form pyrrolocinnolines and with hydrazines to give either the same ring system or a pyrazolocinnoline.Hydrolysis of 3-alkynyl-4phenoxycinnoline to 3-alkynyl-4(1H)-cinnolinone, followed by cyclisation, yields the furocinnoline.Attempts to condense 3-halogenocinnolines with alkenes gave variable results: 3-phenyl ethenyl- and 3(2-pyridylethenyl)-4-(1H)-cinnolinones were obtained but 3-bromocinnoline gave the 3,3'-bicinnolinyl.Action of palladium acetate in the presence of ethyl acrylate converted 3-bromo-4-phenoxycinnoline into benzofurocinnoline and 3-bromo-4-phenylaminocinnoline into indolocinnoline.