82584-73-4Relevant articles and documents
Visible-light assisted of nano Ni/g-C3N4 with efficient photocatalytic activity and stability for selective aerobic C?H activation and epoxidation
Akrami, Zahra,Hosseini-Sarvari, Mona
supporting information, (2020/10/13)
A selective, economical, and ecological protocol has been described for the oxidation of methyl arenes and their analogs to the corresponding carbonyl compounds and epoxidation reactions of alkenes with molecular oxygen (O2) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C3N4 exhibited high photocatalytic activity, stability, and selectivity in the C?H activation of methyl arenes, methylene arenes, and epoxidation of various alkenes under visible- light irradiation without the use of an oxidizing agent and under base free conditions.
Synthesis, Characterization, and Application of Oxo-Molybdenum(V)-Corrolato Complexes in Epoxidation Reactions
Nayak, Manisha,Nayak, Panisha,Sahu, Kasturi,Kar, Sanjib
supporting information, p. 11654 - 11662 (2020/10/23)
Sharpless et al. have described, while performing the molybdenum-catalyzed epoxidation reaction of olefins using alkyl hydroperoxides, that the molybdenum-oxo moiety is an active catalytic species. Thus, continuous efforts have been made to synthesize molybdenum-oxo complexes of different ligand environments. While plenty of such works on molybdenum porphyrins are reported in the literature, related molybdenum corroles are very less reported. The synthesis and characterization of two new oxo-molybdenum(V)-corrolato complexes are described herein. Both the complexes have been fully characterized by several spectroscopic techniques in conjunction with single-crystal X-ray diffraction analysis. The efficacy of the oxo-molybdenum(V)-corrolato complexes for the catalytic epoxidation reaction of olefins with the help of hydroperoxides has also been explored. The catalytic application of oxo-molybdenum(V)-corrolato complexes in the epoxidation reaction has not been reported earlier. A mechanism has been proposed to explain the experimental findings.
Thiourea composite feed additive with urease inhibition activity and preparation method thereof
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Paragraph 0023-0037, (2019/04/29)
The invention discloses a thiourea composite feed additive with urease inhibition activity and a preparation method thereof, and belongs to the technical field of synthesis of feed additives. The technical scheme is characterized in that the compound structure of the thiourea composite feed additives is shown in the description. Compared with the prior art, the thiourea composite feed additive hasthe following beneficial effects: 1, the non-protein nitrogen group and the nitrogen-containing micromolecule urease inhibitor group can be linked together through the hydrophilic group by the feed additive obtained by the method, meanwhile, functions of supplementing non-protein nitrogen and inhibiting urease are provided; 2, the tandem non-protein nitrogen group and the nitrogen-containing small molecule urease inhibitor group are completed by 2-hydroxy propane through oxygen and imino, which is an excellent hydrophilic group, has good water solubility, has a stable molecular structure in vitro, and can effectively release a non-protein nitrogen group and a nitrogen-containing micromolecule urease inhibitor group in gastric juice; 3, the feed additive has no toxic or side effect; 4, themethod has simple operation and high product yield.
Exploring the Biocatalytic Scope of a Novel Enantioselective Halohydrin Dehalogenase from an Alphaproteobacterium
Xue, Feng,Ya, Xiangju,Xiu, Yuansong,Tong, Qi,Wang, Yuqi,Zhu, Xinhai,Huang, He
, p. 629 - 637 (2019/01/25)
A gene encoding halohydrin dehalogenase from an alphaproteobacterium (AbHHDH) was identified, cloned and over-expressed in Escherichia coli. AbHHDH was able to catalyze the stereoselective dehalogenation of prochiral and racemic halohydrins. It showed the highest enantioselectivity in the dehalogenation of 20?mM (R,S)-2-bromo-1-phenylethanol, which yielded (S)-2-bromo-1-phenylethanol with 99% ee and 34.5% yield. Moreover, AbHHDH catalyzed the azidolysis of epoxides with low to moderate (S)-enantioselectivity. The highest enantioselectivity (E = 18.6) was observed when (R,S)-benzyl glycidyl ether was used as the substrate. A sequential kinetic resolution catalyzed by HHDH was employed for the synthesis of chiral 1-chloro-3-phenoxy-2-propanol. We prepared enantiopure (S)-isomer with a high enantiopurity of ee > 99% and a yield of 30.7% (E-value: 21.3) by kinetic resolution of 20?mM substrate. The (S)-isomer with 99% ee readily obtained from 40 to 150?mM (R,S)-1-chloro-3-phenoxy-2-propanol. Taken together, the results of this study demonstrate the applicability of this HHDH for the production of optically active compounds. [Figure not available: see fulltext.].
Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents
Xu, Yao,Chen, Shujun,Cao, Ying,Zhou, Pingzheng,Chen, Zhipeng,Cheng, Kui
, p. 253 - 266 (2018/05/29)
Toll-like receptor 4 (TLR4) initiates innate immune response to release inflammatory cytokines and has been pathologically linked to variety of inflammatory diseases. Recently, we found that Carvedilol, as the classic anti-heart failure and anti-inflammatory clinic drug, could inhibit the TLR4 signaling in the TLR4 overexpressed cells. Herein, we have designed and synthesized a small library of novel Carvedilol derivatives and investigated their potential inhibitory activity. The results indicate that the most potent compound 8a (SMU-XY3) could effectively inhibited TLR4 protein and the LPS triggered alkaline phosphatase signaling in HEK-Blue hTLR4 cells. It down regulated the nitric oxide (NO) in both RAW264.7 cells and BV-2 microglial cells, in addition to blocking the TNF-α signaling in ex-vivo human peripheral blood mononuclear cells (PBMC). More interestingly, 8a shows higher affinity to hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) over HCN2, which probably indicates the new application of TLR4 inhibitor 8a in heart failure, coronary heart disease, and other inflammatory diseases.
Homochiral Metal-Organic Cage for Gas Chromatographic Separations
Xie, Sheng-Ming,Fu, Nan,Li, Li,Yuan, Bao-Yan,Zhang, Jun-Hui,Li, Yan-Xia,Yuan, Li-Ming
, p. 9182 - 9188 (2018/07/21)
Metal-organic cages (MOCs) as a new type of porous material with well-defined cavities were extensively pursued because of their relative ease of synthesis and their potential applications in host-guest chemistry, molecular recognition, separation, catalysis, gas storage, and drug delivery. Here, we first reported that a homochiral MOC [Zn3L2] is explored to fabricate [Zn3L2] coated capillary column for high-resolution gas chromatographic separation of a wide range of analytes, including n-alkanes, polycyclic aromatic hydrocarbons, and positional isomers, especially for racemates. Various kinds of racemates such as alcohols, diols, epoxides, ethers, halohydrocarbons, and esters were separated with good enantioselectivity and reproducibility on the [Zn3L2] coated capillary column. The fabricated [Zn3L2] coated capillary column exhibited significant chiral recognition complementary to that of a commercial β-DEX 120 column and our recently reported homochiral porous organic cage CC3-R coated column. The results show that the homochiral MOCs will be very attractive as a new type of chiral selector in separation science.
Synthetic method of tamoxifen medicine intermediate epibromohydrin
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Paragraph 0007; 0015; 0016, (2016/11/24)
A synthetic method of a tamoxifen medicine intermediate epibromohydrin includes the following steps: 1) adding 5.6 mol of 1-amino-3-bromo-propyl alcohol, 6.1-6.3 mol of a 2-bromophenol solution, 800 ml of a potassium bromide solution, 2.56 mol of aluminum oxide, 700 ml of hexane and 300 ml of a sodium sulfite solution into a reaction container provided with a distilling apparatus; 2) increasing the solution temperature to 70-75 DEG C and performing a reaction for 3-5 h, reducing the solution temperature to 50-55 DEG C, controlling the stirring rate to be 110-150 rpm, performing reflux for 90-110 min, and reducing the solution temperature to 10-13 DEG C, and allowing the solution to stand for 2-5 h to layer the solution; and 3) washing an oil layer successively with a salt solution, acetonitrile and isopropyl alcohol, performing pressure-reduced distillation and collecting the fraction at 80-85 DEG C, and performing re-crystallization in nitromethane to obtain the epibromohydrin crystal.
Manganese(II)/Picolinic Acid Catalyst System for Epoxidation of Olefins
Moretti, Ross A.,Du Bois,Stack, T. Daniel P.
supporting information, p. 2528 - 2531 (2016/07/06)
An in situ generated catalyst system based on Mn(CF3SO3)2, picolinic acid, and peracetic acid converts an extensive scope of olefins to their epoxides at 0 °C in 5 min, with remarkable oxidant efficiency and no evidence of radical behavior. Competition experiments indicate an electrophilic active oxidant, proposed to be a high-valent Mn = O species. Ligand exploration suggests a general ligand sphere motif contributes to effective oxidation. The method is underscored by its simplicity and use of inexpensive reagents to quickly access high value-added products.
Application of homochiral alkylated organic cages as chiral stationary phases for molecular separations by capillary gas chromatography
Xie, Shengming,Zhang, Junhui,Fu, Nan,Wang, Bangjin,Hu, Cong,Yuan, Liming
, (2016/12/03)
Molecular organic cage compounds have attracted considerable attention due to their potential applications in gas storage, catalysis, chemical sensing, molecular separations, etc. In this study, a homochiral pentyl cage compound was synthesized from a condensation reaction of (S,S)-1,2-pentyl-1,2-diaminoethane and 1,3,5-triformylbenzene. The imine-linked pentyl cage diluted with a polysiloxane (OV-1701) was explored as a novel stationary phase for high-resolution gas chromatographic separation of organic compounds. Some positional isomers were baseline separated on the pentyl cage-coated capillary column. In particular, various types of enantiomers including chiral alcohols, esters, ethers and epoxides can be resolved without derivatization on the pentyl cage-coated capillary column. The reproducibility of the pentyl cage-coated capillary column for separation was investigated using nitrochlorobenzene and styrene oxide as analytes. The results indicate that the column has good stability and separation reproducibility after being repeatedly used. This work demonstrates that molecular organic cage compounds could become a novel class of chiral separation media in the near future.
METHOD FOR PURIFYING 2-FLUOROBUTANE
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Paragraph 0048, (2016/06/13)
The present invention is a method for 2-fluorobutane to obtain highly purified 2-fluorobutane through a process comprising a step for: bringing crude 2-fluorobutane that includes 5 to 50 wt % of butene into contact with a brominating agent that can form a bromonium ion in an aprotic polar solvent in the presence of water or an alcohol having up to 4 carbon atoms; converting the butene into compounds having a boiling point higher than that of 2-fluorobutane, then recovering 2-fluorbutane from the reaction solution; and purifying the recovered 2-fluorabutane by distillation.