827624-81-7Relevant articles and documents
Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry
Van Der Wildt, Berend,Shen, Bin,Chin, Frederick T.
supporting information, p. 3124 - 3127 (2019/03/28)
Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.
CHEMICAL COMPOUNDS
-
Page/Page column 92, (2012/02/02)
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
Microwave-promoted aminocarbonylation of aryl triflates using Mo(CO)6 as a solid CO source
Odell, Luke R.,S?vmarker, Jonas,Larhed, Mats
scheme or table, p. 6115 - 6118 (2009/04/04)
Palladium-catalyzed carbonylations of aryl triflates with a range of nucleophiles using Mo(CO)6 as a solid CO source were explored. The reactions proceeded smoothly providing moderate to good yields of the corresponding aryl amides, esters, or acylsulfonamides after only 20 min of microwave irradiation. The acyl transfer reagent 4-dimethylaminopyridine was found to promote some of the more difficult transformations.
