837364-87-1

Basic information

• Product Name: Pyridine, 2-fluoro-4-hydrazino- (9CI)
• Synonyms: Pyridine, 2-fluoro-4-hydrazino- (9CI);2-Fluoro-4-hydrazinopyridine
• CAS NO: 837364-87-1
• Molecular Formula: C5H6FN3
• Molecular Weight: 127.1196432
• Product Categories: PYRIDINE
• Mol File: 837364-87-1.mol

Chemical Properties

• Melting Point: 97-99 °C(Solv: tetrahydrofuran (109-99-9); hexane (110-54-3))
• Boiling Point: 277.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.359±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.16±0.24(Predicted)
• CAS DataBase Reference: Pyridine, 2-fluoro-4-hydrazino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-fluoro-4-hydrazino- (9CI)(837364-87-1)
• EPA Substance Registry System: Pyridine, 2-fluoro-4-hydrazino- (9CI)(837364-87-1)

Safety Data

• Hazardous Substances Data: 837364-87-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Pyridine, 2-fluoro-4-hydrazino(9CI) is used as a building block in the synthesis of various pharmaceutical compounds due to its unique structure and potential biological activities. Its presence in these compounds may contribute to their therapeutic properties, making it a valuable component in drug development.
Used in Medicinal Chemistry:
Pyridine, 2-fluoro-4-hydrazino(9CI) is utilized in medicinal chemistry for its potential to enhance the properties of pharmaceutical compounds. Its incorporation into drug molecules can lead to improved efficacy, selectivity, and pharmacokinetics, which are crucial for the development of effective therapeutic agents.
Used in Drug Discovery:
Pyridine, 2-fluoro-4-hydrazino(9CI) is employed in drug discovery processes to explore its potential therapeutic properties. Further research and development of this compound are warranted to understand its full potential in treating various diseases and conditions.

Upstream product

• 3512-17-2 2,4,6-trifluoropyridine 
• 837364-98-4 2,4-difluoro-6-hydrazinopyridine 
• 837364-96-2 2,4-difluoro-6-hydrazino-3-(triethylsilyl)pyridine 
• 837364-95-1 2,4,6-trifluoro-3-(triethylsilyl)pyridine 
• 34941-90-7 2,4-difluoropyridine 

Relevant articles and documents

Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick

(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.

Rerouting nucleophilic substitution from the 4-position to the 2- or 6-position of 2,4-dihalopyridines and 2,4,6-trihalopyridines: The solution to a long-standing problem

(Chemical Equation Presented) 2,4-Difluoro-, 2,4,6-trifluoro-, and 2,3,4,6-tetrafluoropyridine undergo nucleophilic substitution preferentially if not exclusively at the 4-position. However, after the introduction of a trialkylsilyl group at C-3 or C-5, t