837364-98-4

Basic information

• Product Name: (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE;2,4-difluoro-6-hydrazinyl-Pyridine;4,6-Difluoro-2-hydrazono-2,3-dihydropyridine
• CAS NO: 837364-98-4
• Molecular Formula: C5H5F2N3
• Molecular Weight: 145.1101064
• Mol File: 837364-98-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE(837364-98-4)
• EPA Substance Registry System: (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE(837364-98-4)

Safety Data

• Hazardous Substances Data: 837364-98-4(Hazardous Substances Data)

Usage

General Description

(4,6-Difluoro-pyridin-2-yl)-hydrazine is a chemical compound with the molecular formula C5H5F2N3. It is a pale yellow solid that is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE is known for its potent antibacterial and antifungal properties, making it a valuable component in the development of new medications. It can be used as a reagent in organic synthesis and as an intermediate in the production of other chemical compounds. Additionally, (4,6-Difluoro-pyridin-2-yl)-hydrazine has potential applications in the field of materials science and is the subject of ongoing research for its various properties and potential uses.

Upstream product

• 837364-96-2 2,4-difluoro-6-hydrazino-3-(triethylsilyl)pyridine 
• 837364-95-1 2,4,6-trifluoro-3-(triethylsilyl)pyridine 
• 3512-17-2 2,4,6-trifluoropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 

Downstream Products

• 34941-90-7 2,4-difluoropyridine 
• 41404-63-1 2-bromo-4,6-difluoropyridine 
• 837364-91-7 4-fluoro-2-hydrazino-5-(trimethylsilyl)pyridine 
• 849937-90-2 2,4-difluoro-3-pyridinecarboxylic acid 
• 849937-89-9 4,6-difluoro(pyridin-2-yl)carboxylic acid 
• 849937-91-3 4,6-difluoro-3-pyridinecarboxylic acid 
• 837364-89-3 2,4-difluoro-5-iodopyridine 
• 837364-88-2 2,4-difluoro-3-iodopyridine 
• 837364-87-1 2-fluoro-4-hydrazineylpyridine 
• 849937-80-0 2-fluoro-N,N-dimethylpyridin-4-amine 

Relevant articles and documents

Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick

(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.