837364-98-4

Usage

Uses

Used in Pharmaceutical Industry:
(4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE is used as a building block for the synthesis of various pharmaceuticals due to its potent antibacterial and antifungal properties. It contributes to the development of new medications that can effectively combat bacterial and fungal infections.
Used in Agrochemical Industry:
In the agrochemical industry, (4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE is utilized as a component in the development of pesticides and fungicides. Its potent properties help protect crops from bacterial and fungal diseases, ensuring higher yields and better crop quality.
Used in Organic Synthesis:
(4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE is used as a reagent in organic synthesis, facilitating the formation of various chemical compounds. Its unique structure and properties make it a valuable component in the synthesis of complex organic molecules.
Used in Materials Science:
(4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE has potential applications in the field of materials science. Ongoing research explores its properties and potential uses in developing new materials with unique characteristics, such as enhanced stability, reactivity, or other desirable properties.
Used as an Intermediate in Chemical Production:
(4,6-DIFLUORO-PYRIDIN-2-YL)-HYDRAZINE is used as an intermediate in the production of other chemical compounds. Its versatile structure allows it to be a key component in the synthesis of a wide range of chemicals, contributing to the development of new products and technologies.

Upstream product

• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 3512-17-2 2,4,6-trifluoropyridine 
• 837364-95-1 2,4,6-trifluoro-3-(triethylsilyl)pyridine 
• 837364-96-2 2,4-difluoro-6-hydrazino-3-(triethylsilyl)pyridine 

Downstream Products

• 837364-91-7 4-fluoro-2-hydrazino-5-(trimethylsilyl)pyridine 
• 849937-90-2 2,4-difluoro-3-pyridinecarboxylic acid 
• 849937-89-9 4,6-difluoro(pyridin-2-yl)carboxylic acid 
• 849937-91-3 4,6-difluoro-3-pyridinecarboxylic acid 
• 837364-89-3 2,4-difluoro-5-iodopyridine 
• 837364-88-2 2,4-difluoro-3-iodopyridine 
• 837364-87-1 2-fluoro-4-hydrazineylpyridine 
• 849937-80-0 2-fluoro-N,N-dimethylpyridin-4-amine 
• 41404-63-1 2-bromo-4,6-difluoropyridine 
• 34941-90-7 2,4-difluoropyridine 

Relevant academic research and scientific papers

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.

Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick

(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.

Rerouting nucleophilic substitution from the 4-position to the 2- or 6-position of 2,4-dihalopyridines and 2,4,6-trihalopyridines: The solution to a long-standing problem

(Chemical Equation Presented) 2,4-Difluoro-, 2,4,6-trifluoro-, and 2,3,4,6-tetrafluoropyridine undergo nucleophilic substitution preferentially if not exclusively at the 4-position. However, after the introduction of a trialkylsilyl group at C-3 or C-5, t