846021-26-9

Basic information

• Product Name: 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID
• Synonyms: 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 2-amino-6-methyl-;2-amino-6-methylpyridine-3-carboxylic acid
• CAS NO: 846021-26-9
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Mol File: 846021-26-9.mol

Chemical Properties

• Boiling Point: 339.9°C at 760 mmHg
• Flash Point: 159.4°C
• Appearance: /
• Density: 1.337g/cm³
• Vapor Pressure: 3.45E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID(846021-26-9)
• EPA Substance Registry System: 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID(846021-26-9)

Safety Data

• Hazardous Substances Data: 846021-26-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID is used as a precursor in the production of various drugs and substances, contributing to the development of new medications and therapies.
Used in Chemical Research:
2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID is utilized as a key building block in the synthesis of organic compounds, enabling the creation of novel chemical entities for various applications.
Used in Agricultural Chemicals:
2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID is employed in the development and production of pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and yield.
Used in Material Science and Technology Development:
Due to its unique chemical properties, 2-AMINO-6-METHYL-3-PYRIDINECARBOXYLIC ACID has potential applications in the development of new materials and technologies, paving the way for innovative solutions in various industries.

InChI:InChI=1/C7H8N2O2/c1-4-2-3-5(7(10)11)6(8)9-4/h2-3H,1H3,(H2,8,9)(H,10,11)

Upstream product

• 84647-20-1 2-amino-6-methylpyridine-3-carbonitrile 
• 100524-09-2 2-amino-6-methylnicotinamide 
• 70959-85-2 ethyl 2-amino-6-methylnicotinate 
• 82417-87-6 2-acetylamino-6-methyl-nicotinic acid ethyl ester 
• 1359763-35-1 2-(2,2-dimethylpropionylamino)-6-methylnicotinic acid 
• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 28900-10-9 2-chloro-6-methylnicotinonitrile 
• 4241-27-4 2-hydroxy-6-methylnicotinonitrile 

Downstream Products

• 98953-24-3 2-acetylamino-6-methyl-nicotinic acid 
• 36075-35-1 7-methyl-1H-pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 1005490-28-7 C₁₄H₁₂N₄O 
• 853680-66-7 (7S,2R)-{1-(4-chlorobenzyl)-2-[4-(7-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester 
• 853680-62-3 (7S)-4-[7-methyl-8-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 853680-63-4 (7R)-4-[7-methyl-8-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 117890-81-0 4-chloro-7-methyl-pyrido[2,3-d]pyrimidine 
• 1185090-06-5 N-[4-(phenoxymethyl)phenyl]methyl-2-amino-6-methylnicotinic acid amide 
• 1185090-08-7 N-(2-fluorophenyl)methyl-2-amino-6-chloronicotinic acid amide 
• 1185089-80-8 N-(4-benzylphenyl)methyl-2-amino-6-methylnicotinic acid amide 
• 1185089-77-3 N-[4-(2-phenylethyl)phenyl]methyl-2-amino-6-methylnicotinic acid amide 
• 1185090-00-9 N-[3-(3-methylphenyloxy)phenyl]methyl-2-amino-6-methylnicotinic acid amide 
• 1185090-01-0 N-(3-pentylphenyl)methyl-2-amino-6-methylnicotinic acid amide 
• 1185089-94-4 N-(2-fluoro-3-methoxyphenyl)methyl-2-amino-6-methylnicotinic acid amide 

Relevant articles and documents

Method for producing 2-amino-6-methylnicotinic acid

The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III] with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I].

2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: A step toward new antiexcitotoxic agents

3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharmacological investigation on its role in the pathogenesis of these conditions is difficult because only one class of substrate-analogue 3-HAO inhibitors, with poor chemical stability, has been reported so far. Here we describe the design, synthesis, and biological evaluation of a novel class of chemically stable inhibitors based on the 2-aminonicotinic acid 1-oxide nucleus. After the preliminary in vitro evaluation of newly synthesized compounds using brain tissue homogenate, we selected the most active inhibitor and showed its ability to acutely reduce the production of QUIN in the rat brain in vivo. These findings provide a novel pharmacological tool for the study of the mechanisms underlying the onset and propagation of neurodegenerative diseases.

COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS

Disclosed is a composition for agricultural use, which is used for controlling or preventing plant diseases caused by plant pathogens. The composition for agricultural use contains a compound represented by formula (1), a salt thereof or a hydrate of the compound or the salt. (1) [In the formula, Z represents an oxygen atom, a sulfur atom or NRz; and E represents a furyl group, a thienyl group, a pyrrolyl group, a tetrazolyl group, a thiazolyl group, a pyrazolyl group, a phenyl group or the like.]

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.