847248-48-0Relevant articles and documents
Preparation method of quinoline amide compounds
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Paragraph 0027-0028, (2020/12/10)
The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method of quinoline amide compounds, which comprises the following steps: (1) adding quinoline carboxylic acid compounds and thiuram into an organic solvent to react to obtain a reaction solution; and (2) separating and purifying the reaction solution obtained in the step (1). According to the invention, a one-pot boiling method is adopted, an economical and easily available quinoline carboxylic acid compound and thiuram are used as raw materials, and an amidation reaction is directly carried out in air to generate the corresponding quinoline amide compound. The synthesis system is wide in application range, compatible with functional groups such as quinolyl and acylamino, simple inprocess, convenient to operate, mild in reaction condition, wide in substrate range, high in yield and suitable for application and popularization.
Design of novel nicotinic ligands through 3D database searching
Guandalini, Luca,Martini, Elisabetta,Dei, Silvia,Manetti, Dina,Scapecchi, Serena,Teodori, Elisabetta,Romanelli, M. Novella,Varani, Katia,Greco, Giovanni,Spadola, Loredana,Novellino, Ettore
, p. 799 - 807 (2007/10/03)
A series of quinoline derivatives have been designed on the basis of results from a 3D search of the Cambridge Structural Database using the nicotinic pharmacophore as a query and further modified using molecular modeling. Some of the synthesized compound
