847556-27-8

Basic information

• Product Name: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride
• Synonyms: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride;3,3-diphenyl-6,7,8,8a-tetrahydro-5H-[1,3]oxazolo[3,4-a]pyrazin-1-one:hydrochloride
• CAS NO: 847556-27-8
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 330.80866
• Mol File: 847556-27-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride(847556-27-8)
• EPA Substance Registry System: 1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride(847556-27-8)

Safety Data

• Hazardous Substances Data: 847556-27-8(Hazardous Substances Data)

Usage

Molecular Structure

1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride has a complex molecular structure consisting of a tetrahydrooxazolo-pyrazinone core with two phenyl groups attached to the 1,1-positions.

Appearance

It is a white crystalline powder.

Usage

Often used in pharmaceutical research and drug development.

Therapeutic Applications

Has potential therapeutic applications due to its ability to interact with biological systems.

Building Block

Commonly used as a building block in the synthesis of various pharmaceutical compounds.

Value in Medicinal Chemistry

Its properties make it a valuable tool for researchers in the field of medicinal chemistry.

Salt Form

The hydrochloride salt form of this compound.

Solubility

Water-soluble, making it suitable for use in various drug formulations and drug delivery systems.

Pharmaceutical Applications

1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride is an important chemical compound with potential pharmaceutical applications.

Upstream product

• 847555-98-0 7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one 
• 17532-22-8 (1,4-dibenzyl-piperazin-2-yl)-diphenyl-methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17532-20-6 diphenyl(piperazin-2-yl)methanol 
• 591-51-5 phenyllithium 
• 847553-76-8 3-oxo-1,1-diphenyltetrahydrooxazolo[3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

Identification of neuropeptide s antagonists: Structure-Activity relationship studies, x-ray crystallography, and in vivo evaluation

Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyr

Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity

A series of 7-substituted 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones were synthesized and tested for Neuropeptide S (NPS) antagonist activity. A concise synthetic route was developed, which features a DMAP catalyzed carbamate formation. 4-Fluorob

BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF

The present invention provides a compound represented by the formula: wherein R1 is an acyl group, R2 is a hydrocarbon group which may be substituted or the like, R3 is a hydrocarbon group which may be substituted or the like, R4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, a sulfur atom or the like, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.