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N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL, also known as NiPAG, is a chemical compound that consists of a nickel atom coordinated with a glycinate ligand and a Schiff base ligand derived from piperidinoacetamido-phenyl-benzylidene. It is commonly used as a catalyst in various organic reactions, including the synthesis of pharmaceuticals, organic compounds, and polymerization processes. NiPAG has gained attention due to its low toxicity and high catalytic activity, making it an attractive alternative to other nickel-based catalysts. Its unique structure and reactivity make it a promising candidate for a wide range of applications in chemical synthesis and industrial processes.

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  • N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL

    Cas No: 847654-17-5

  • USD $ 1.9-2.9 / Gram

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  • 847654-17-5 Structure
  • Basic information

    1. Product Name: N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL
    2. Synonyms: N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL;[N-[α-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel;[N-[α-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel
    3. CAS NO:847654-17-5
    4. Molecular Formula: C22H23N3NiO3
    5. Molecular Weight: 436.135
    6. EINECS: N/A
    7. Product Categories: Classes of Metal Compounds;Glycine Equivalents;Ni (Nickel) Compounds;Synthetic Organic Chemistry;Transition Metal Compounds
    8. Mol File: 847654-17-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: soluble in Chloroform
    9. CAS DataBase Reference: N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL(847654-17-5)
    11. EPA Substance Registry System: N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL(847654-17-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 847654-17-5(Hazardous Substances Data)

847654-17-5 Usage

Uses

Used in Pharmaceutical Industry:
NiPAG is used as a catalyst for the synthesis of pharmaceuticals, enabling the production of various drugs and medications. Its high catalytic activity and low toxicity make it an attractive alternative to other nickel-based catalysts, improving the efficiency and safety of pharmaceutical manufacturing processes.
Used in Organic Compound Synthesis:
NiPAG is used as a catalyst in the synthesis of organic compounds, facilitating the production of various chemicals and materials. Its unique structure and reactivity allow for efficient and selective reactions, making it a valuable tool in the synthesis of complex organic molecules.
Used in Polymerization Processes:
NiPAG is used as a catalyst in polymerization processes, enabling the production of various types of polymers. Its catalytic properties allow for controlled polymerization, resulting in polymers with specific properties and applications.
Used in Chemical Synthesis:
NiPAG is used as a catalyst in a wide range of chemical synthesis applications, promoting efficient and selective reactions. Its unique structure and reactivity make it a promising candidate for various chemical synthesis processes, improving the overall efficiency and selectivity of these reactions.
Used in Industrial Processes:
NiPAG is used as a catalyst in various industrial processes, including the production of chemicals, materials, and pharmaceuticals. Its low toxicity and high catalytic activity make it an attractive alternative to other nickel-based catalysts, improving the efficiency and safety of industrial processes.

Check Digit Verification of cas no

The CAS Registry Mumber 847654-17-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,6,5 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 847654-17:
(8*8)+(7*4)+(6*7)+(5*6)+(4*5)+(3*4)+(2*1)+(1*7)=205
205 % 10 = 5
So 847654-17-5 is a valid CAS Registry Number.

847654-17-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name [<i>N</i>-[α-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel

1.2 Other means of identification

Product number -
Other names nickel(2+),2-[[[2-[(1-oxido-2-piperidin-1-ylethylidene)amino]phenyl]-phenylmethylidene]amino]acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:847654-17-5 SDS

847654-17-5Relevant articles and documents

Base-Promoted Synthesis of β-Substituted-Tryptophans via a Simple and Convenient Three-Component Condensation of Nickel(II) Glycinate

Zhou, Rui,Pan, Zhaoping,Zhang, Yuehua,Wu, Fengbo,Jiang, Qinglin,Guo, Li

, (2017)

A three-component reaction of nickel(II) glycinate was conducted for the convenient synthesis of β-substituted-Tryptophans. The reaction worked smoothly under mild conditions and the procedure was simple and easy to handle.

Synthesis of trifluoromethyl substituted nucleophilic glycine equivalents and the investigation of their potential for the preparation of α-amino acids

Bergagnini-Kolev, Mackenzie,Howe, Mitchell,Burgess, Emily,Wright, Payton,Hamburger, Samantha,Zhong, Zhennan,Ellis, Shawna B.,Ellis, Trevor K.

supporting information, (2020/12/02)

The synthetic preparation of several Ni(II) complexed Schiff Bases of glycine will be introduced, as well as investigations into their reactivity and utility. Key to these investigations is the incorporation of electron-withdrawing trifluoromethyl groups within the framework of the conjugated system that stabilizes the enolate derived from the glycine component. Reactivity was evaluated for each of the complexes under phase transfer catalyzed alkylations with hydroxide bases, as well as the DBU catalyzed Michael Additions of optically active 3′-substituted-2-oxazoladinone amides of unsaturated carboxylic acids. It was found that the trifluoromethyl containing nucleophilic glycine equivalents were more reactive than their non-trifluoromethyl analogues in both reaction types. Therefore, the application of these modified Ni(II) complexes of glycine Schiff Bases are useful for the preparation of α-amino acids through phase transfer catalyzed alkylation as well as the preparation of optically pure β-substituted pyroglutamic acid precursors.

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