[N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel

Base Information

• Chemical Name: [N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel
• CAS No.: 847654-17-5
• Molecular Formula: C22H23 N3 Ni O3
• Molecular Weight: 436.133
• European Community (EC) Number: 678-458-1
• Mol file: 847654-17-5.mol

Synonyms:847654-17-5;[N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel;N-[ALPHA-[2-(PIPERIDINOACETAMIDO)PHENYL]BENZYLIDENE]GLYCINATO]NICKEL;MFCD10566925;T72993;[N-[-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel

Chemical Property of [N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel

Chemical Property:

• PSA: 62.21000
• LogP: 2.25320
• Solubility.: soluble in Chloroform
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 436.117108
• Heavy Atom Count: 29
• Complexity: 558

Purity/Quality:

98% ^*data from raw suppliers

[N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel >93.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CC(=O)[N-]C2=CC=CC=C2C(=NCC(=O)O)C3=CC=CC=C3.[Ni]

Technology Process of [N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel

There total 3 articles about [N-[alpha-[2-(Piperidinoacetamido)phenyl]benzylidene]glycinato]nickel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

nickel(II) nitrate hexahydrate + glycine (56-40-6,18875-39-3,25718-94-9) + N-(2-benzoylphenyl)-2-(piperidin-1-yl)acetamide (615576-88-0) → [Ni(C5H10NCH2C(O)NC6H4C(C6H5)NCH2CO2)] (847654-17-5)

Guidance literature:

With potassium hydroxide; In methanol; at 60 - 70 ℃;

DOI:10.1016/j.tet.2020.131741

Reference yield:

(2-aminophenyl)(phenyl)methanone (2835-77-0) → [Ni(C5H10NCH2C(O)NC6H4C(C6H5)NCH2CO2)] (847654-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

3: potassium hydroxide / methanol / 60 - 70 °C

With potassium carbonate; potassium hydroxide; In methanol; acetonitrile;

DOI:10.1016/j.tet.2020.131741

Reference yield:

2'-benzoyl-2-bromo-acetanilide (14439-71-5) → [Ni(C5H10NCH2C(O)NC6H4C(C6H5)NCH2CO2)] (847654-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere

2: potassium hydroxide / methanol / 60 - 70 °C

With potassium carbonate; potassium hydroxide; In methanol; acetonitrile;

DOI:10.1016/j.tet.2020.131741

upstream raw materials:

glycine

N-(2-benzoylphenyl)-2-(piperidin-1-yl)acetamide

(2-aminophenyl)(phenyl)methanone

2'-benzoyl-2-bromo-acetanilide

Downstream raw materials:

[Ni₂((CH₂)5NCH₂CONC₆H₄C(C₆H₅)N)2]

[Ni((C₆H₅CH₂)2NCH₂C(O)NC₆H₄C(N)C₆H₅)]2

[Ni(C₅H₁₀NCH₂C(O)NC₆H₄C(N)C₆H₅)]2

[Ni₂((C₆H₅CH₂)2NCH₂C(O)NC₆H₄C(N)C₆H₅)(C₅H₁₀NCH₂C(O)NC₆H₄C(N)C₆H₅)]