847805-31-6

Basic information

• Product Name: (S)-N-Boc-2-morpholinecarbaldehyde
• Synonyms: (S)-N-Boc-2-morpholinecarbaldehyde;tert-Butyl (2S)-2-formylmorpholine-4-carboxylate;(S)-4-Boc-2-formyl-morpholine
• CAS NO: 847805-31-6
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.247
• Mol File: 847805-31-6.mol

Chemical Properties

• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 140.7°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.000655mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (S)-N-Boc-2-morpholinecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-2-morpholinecarbaldehyde(847805-31-6)
• EPA Substance Registry System: (S)-N-Boc-2-morpholinecarbaldehyde(847805-31-6)

Safety Data

• Hazardous Substances Data: 847805-31-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-N-Boc-2-morpholinecarbaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Allergy Treatment:
(S)-N-Boc-2-morpholinecarbaldehyde is used as a zwitterionic chemokine receptor, specifically a CCR3 antagonist, with selectivity and outstanding pharmacokinetics. This makes it a promising candidate for the development of allergy treatments, as it can potentially modulate the immune response and alleviate allergic symptoms.
Used in Drug Discovery and Development:
Due to its unique structure and properties, (S)-N-Boc-2-morpholinecarbaldehyde can be employed in drug discovery and development processes. It can be used to design and synthesize novel compounds with potential therapeutic effects, contributing to the advancement of medicine and healthcare.

InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h7-8H,4-6H2,1-3H3/t8-/m0/s1

Upstream product

• 135065-76-8 tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 132073-83-7 (S)-morpholin-2-ylmethanol 
• 847805-30-5 (6S)-6-(hydroxymethyl)morpholin-3-one 
• 847805-29-2 (-)-2-chloro-N-((S)-2,3-dihydroxypropyl)acetamide 
• 868689-63-8 (S)-2,4-morpholinedicarboxylic acid 4-(1,1-dimethylethyl)ester 

Downstream Products

• 847805-33-8 (+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester 
• 847805-32-7 (+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester 
• 71620-89-8 (S,S)-reboxetine 
• 847805-34-9 (+)-(2S,3S)-2-[α-(2-ethoxyphenoxy)phenylmethyl]morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

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Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors

As part of a discovery effort aimed at identifying novel norepinephrine reuptake inhibitors (NRIs), a number of substituted morpholines were designed and synthesized. The target compounds contain vicinal stereogenic centers, and the program was greatly facilitated by the adoption of efficient synthetic routes which allowed for the late stage incorporation of structural and physicochemical diversity into the targets. Structure-activity relationships were developed by optimizing individual ring components of the structure for NRI potency and for selectivity against other monoamine reuptake transporters. Several novel morpholine derivatives with a potent and selective NRI profile are described.

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