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CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER

    Cas No: 848472-36-6

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  • 848472-36-6 Structure
  • Basic information

    1. Product Name: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER
    2. Synonyms: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER;(4,6-Dimethyl-2-pyridinyl)carbamic acid tert-butyl ester;2-(Boc-amino)-4,6-dimethylpyridine;tert-Butyl (4,6-dimethyl-2-pyridinyl)carbamate
    3. CAS NO:848472-36-6
    4. Molecular Formula: C12H18N2O2
    5. Molecular Weight: 222.286
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 848472-36-6.mol
  • Chemical Properties

    1. Melting Point: 75-79°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER(848472-36-6)
    11. EPA Substance Registry System: CARBAMIC ACID, N-(4,6-DIMETHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER(848472-36-6)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 848472-36-6(Hazardous Substances Data)

848472-36-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 848472-36-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,4,7 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 848472-36:
(8*8)+(7*4)+(6*8)+(5*4)+(4*7)+(3*2)+(2*3)+(1*6)=206
206 % 10 = 6
So 848472-36-6 is a valid CAS Registry Number.

848472-36-6 Well-known Company Product Price

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  • Aldrich

  • (748145)  2-(Boc-amino)-4,6-dimethylpyridine  97%

  • 848472-36-6

  • 748145-1G

  • 650.52CNY

  • Detail
  • Aldrich

  • (748145)  2-(Boc-amino)-4,6-dimethylpyridine  97%

  • 848472-36-6

  • 748145-1G

  • 650.52CNY

  • Detail
  • Aldrich

  • (748145)  2-(Boc-amino)-4,6-dimethylpyridine  97%

  • 848472-36-6

  • 748145-1G

  • 650.52CNY

  • Detail
  • Aldrich

  • (748145)  2-(Boc-amino)-4,6-dimethylpyridine  97%

  • 848472-36-6

  • 748145-1G

  • 650.52CNY

  • Detail

848472-36-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(4,6-dimethylpyridin-2-yl)carbamate

1.2 Other means of identification

Product number -
Other names tert-Butyl (4,6-dimethyl-2-pyridinyl)carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:848472-36-6 SDS

848472-36-6Downstream Products

848472-36-6Relevant articles and documents

Overcoming mutagenicity and ion channel activity: Optimization of selective spleen tyrosine kinase inhibitors

Ellis, J. Michael,Altman, Michael D.,Bass, Alan,Butcher, John W.,Byford, Alan J.,Donofrio, Anthony,Galloway, Sheila,Haidle, Andrew M.,Jewell, James,Kelly, Nancy,Leccese, Erica K.,Lee, Sandra,Maddess, Matthew,Miller, J. Richard,Moy, Lily Y.,Osimboni, Ekundayo,Otte, Ryan D.,Reddy, M. Vijay,Spencer, Kerrie,Sun, Binyuan,Vincent, Stella H.,Ward, Gwendolyn J.,Woo, Grace H. C.,Yang, Chiming,Houshyar, Hani,Northrup, Alan B.

supporting information, p. 1929 - 1939 (2015/04/27)

Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of cores within a selected chemical space focused on ligand binding efficiency. Attenuation of hERG ion channel activity inherent within the initial chemotype was guided through modulation of physicochemical properties including log D, PSA, and pKa. PSA proved most effective for prospective compound design. Further profiling of an advanced compound revealed bacterial mutagenicity in the Ames test using TA97a Salmonella strain, and subsequent study demonstrated that this mutagenicity was pervasive throughout the series. Identification of intercalation as a likely mechanism for the mutagenicity-enabled modification of the core scaffold. Implementation of a DNA binding assay as a prescreen and models in DNA allowed resolution of the mutagenicity risk, affording molecules with favorable potency, selectivity, pharmacokinetic, and off-target profiles.

SPECIFIC NNOS INHIBITORS FOR THE THERAPY AND PREVENTION OF HUMAN MELANOMA

-

Page/Page column 12-13, (2012/07/28)

Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives

Ji, Haitao,Delker, Silvia L.,Li, Huiying,Martásek, Pavel,Roman, Linda J.,Poulos, Thomas L.,Silverman, Richard B.

scheme or table, p. 7804 - 7824 (2011/02/25)

Neuronal nitric oxide synthase (nNOS) represents an important therapeutic target for the prevention of brain injury and the treatment of various neurodegenerative disorders. A series of trans-substituted amino pyrrolidinomethyl 2-aminopyridine derivatives

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping

Ji, Haitao,Li, Huiying,Martásek, Pavel,Roman, Linda J.,Poulos, Thomas L.,Silverman, Richard B.

scheme or table, p. 779 - 797 (2009/12/07)

Selective inhibition of neuronal nitric oxide synthase (nNOS) has been shown to prevent brain injury and is important for the treatment of various neurodegenerative disorders. This study shows that not only greater inhibitory potency and isozyme selectivity but more druglike properties can be achieved by fragment hopping. On the basis of the structure of lead molecule 6, fragment hopping effectively extracted the minimal pharmacophoric elements in the active site of nNOS for ligand hydrophobic and steric interactions and generated appropriate lipophilic fragments for lead optimization. More potent and selective inhibitors with better druglike properties were obtained within the design of 20 derivatives (compounds 7-26). Our structure - based inhibitor design for nNOS and SAR analysis reveal the robustness and efficiency of fragment hopping in lead discovery and structural optimization, which implicates a broad application of this approach to many other therapeutic targets for which known druglike small-molecule modulators are still limited.

NOS INHIBITORS FOR TREATMENT OF MOTOR DEFICIT DISORDERS

-

Page/Page column 4; 5/8, (2008/06/13)

The present invention relates to preventive therapies and treatments of motor deficit disorders. In particular, the present invention relates to compositions and methods for preventative therapy and treatment of motor deficit disorders, such as cerebral p

POTENT AND HIGHLY SELECTIVE HETEROAROMATIC INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE

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Page/Page column 33; 35, (2008/06/13)

Peptidomimetic compounds as can inhibit neuronal nitric oxide synthase (nNOS) for potential treatment in neurodegenerative diseases, such as but not limited to stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease.

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