85047-08-1

Basic information

• Product Name: ETHANOL-1,1,2,2-D4-AMINE
• Synonyms: ETHANOLAMINE (D4);ETHANOL-1,1,2,2-D4-AMINE;2-Amino(ethanol-1,1,2,2-d4);Ethanol--d4-aMine;2-AMino-ethan-1,1,2,2-d4-ol;Ethanol-1,1,2,2-d;2-amino-1,1,2,2-tetradeuterioethanol
• CAS NO: 85047-08-1
• Molecular Formula: C₂H₇NO
• Molecular Weight: 65.11
• Mol File: 85047-08-1.mol

Chemical Properties

• Melting Point: 11 °C(lit.)
• Boiling Point: 170 °C(lit.)
• Flash Point: 93 °C
• Appearance: /
• Density: 1.080 g/mL at 25 °C
• CAS DataBase Reference: ETHANOL-1,1,2,2-D4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHANOL-1,1,2,2-D4-AMINE(85047-08-1)
• EPA Substance Registry System: ETHANOL-1,1,2,2-D4-AMINE(85047-08-1)

Safety Data

• Hazard Codes: Xn,C
• Statements: 20-36/37/38-34-20/21/22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2491 8/PG 3
• WGK Germany: 1
• Hazardous Substances Data: 85047-08-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
ETHANOL-1,1,2,2-D4-AMINE is used as a solvent or intermediate in organic synthesis for its unique properties that facilitate specific chemical reactions. The presence of deuterium atoms enhances its reactivity and stability, making it suitable for a range of applications in the synthesis of complex organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, ETHANOL-1,1,2,2-D4-AMINE is used as a key component in the development of new drugs. Its ability to form salts with acids can be leveraged to improve the solubility and bioavailability of certain pharmaceutical compounds, potentially leading to more effective treatments.
Used in Specialty Chemicals:
ETHANOL-1,1,2,2-D4-AMINE is employed in the production of specialty chemicals due to its distinctive properties. The deuterated form of ethanolamine can be integrated into the synthesis of high-performance materials, such as polymers and coatings, where its enhanced stability and reactivity contribute to improved product performance.
Used in Chemical Reactions:
ETHANOL-1,1,2,2-D4-AMINE is utilized in various chemical reactions for its capacity to react with acids and form salts. This characteristic makes it a valuable agent in processes that require the formation of specific salts or the alteration of the chemical properties of other compounds.

Upstream product

• 946524-40-9 N-(2-hydroxyethyl-1,1,2,2-⁽²⁾H₄)-5Z,8Z,11Z,14Z-eicosatetraenamide 
• 4896-75-7 <2-2H2>glycine 

Downstream Products

• 1542204-48-7 2-((1,2-[²H₄]-2-hydroxyethyl)amino)-1-ethyl-7-(4-methoxybenzyl)-1H-purin-6(7H)-one 
• 946524-43-2 4,7,10,13,16,19-docosahexaenoyl ethanolamide-d4 
• 1442117-44-3 Benzyl N-(2-hydroxy[²H₄]ethyl)carbamate 
• 1169692-38-9 2-aminoethyl dihydrogen phosphate-1,1,2,2-d4 
• 946524-40-9 N-(2-hydroxyethyl-1,1,2,2-⁽²⁾H₄)-5Z,8Z,11Z,14Z-eicosatetraenamide 
• 946524-41-0 5,8,11,14,17-eicosapentaenoyl ethanolamide-d4 
• 946524-34-1 palmitoyl ethanolamide-d4 
• 946524-36-3 oleoyl ethanolamide-d4 
• 918633-70-2 2-bromoethyl-1,1,2,2,-d₄-amine hydrobromide 

Relevant articles and documents

Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity

Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the hydrolysis of the endocannabinoid anandamide (arachidonoyl ethanolamide, AEA) to arachidonic acid (AA) and ethanolamine (EA). Published FAAH activity assays mostly employ radiolabeled anandamide or synthetic fluorogenic substrates. We report a stable isotope liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for specific, sensitive, and high-throughput capable FAAH activity measurements. The assay uses AEA labeled with deuterium on the EA moiety (d4-AEA) as substrate and measures the specific reaction product tetradeutero-EA (d4-EA) and the internal standard 13C2-EA. Selected reaction monitoring of m/z 66 → m/z 48 (d4-EA) and m/z 64 → m/z 46 (13C2-EA) in the positive electrospray ionization mode after liquid chromatographic separation on a HILIC (hydrophilic interaction liquid chromatography) column is performed. The assay was developed and thoroughly validated using recombinant human FAAH (rhFAAH) and then was applied to human blood and dog liver samples. rhFAAH-catalyzed d4-AEA hydrolysis obeyed Michaelis-Menten kinetics (KM = 12.3 μM, Vmax = 27.6 nmol/min mg). Oleoyl oxazolopyridine (oloxa) was a potent, partial noncompetitive inhibitor of rhFAAH (IC50 = 24.3 nM). Substrate specificity of other fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton. In human whole blood, we detected FAAH activity that was inhibited by oloxa.

Improved CILAT reagents for quantitative proteomics

Improved CILAT reagents have been developed, with which an unprecedented number of protein samples can be measured in high-throughput assays, providing a robust tool for MS-based quantitative proteomics.