85111-06-4

Basic information

• Product Name: 2-METHYL-3-PROPIONYLINDOLE
• Synonyms: 2-METHYL-3-PROPIONYLINDOLE;1-(2-methyl-1H-indol-3-yl)propan-1-one
• CAS NO: 85111-06-4
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.23772
• Mol File: 85111-06-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYL-3-PROPIONYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3-PROPIONYLINDOLE(85111-06-4)
• EPA Substance Registry System: 2-METHYL-3-PROPIONYLINDOLE(85111-06-4)

Safety Data

• Hazardous Substances Data: 85111-06-4(Hazardous Substances Data)

Upstream product

• 79-03-8 propionyl chloride 
• 95-20-5 2-methyl-1H-indole 
• 75-91-2 tert.-butylhydroperoxide 
• 123-38-6 propionaldehyde 
• 3002-24-2 hexane-2,4-dione 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 89-52-1 o-acetylamino-benzoic acid 

Relevant articles and documents

One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere

A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.

Regiocontrolled direct C4 and C2-methyl thiolation of indoles under rhodium-catalyzed mild conditions

A straightforward Rh(iii)-catalyzed general strategy was developed for the site-selective remote C4 (sp2) and C2 (sp3)-methyl thiolation of an indole core, keeping the oxime directing group at the C3 position. The transformation was accomplished under mild conditions with a wide scope and functional group tolerance. The directing group can easily be removed after operation. Methyl substitution at the C2 position of the indole core led to C2 (sp3)-methyl thiolation.

Copper-catalyzed synthesis of 2,3-disubstituted indoles from ortho-haloanilines and β-keto esters/β-diketone

Tetrazole-1-acetic acid was identified as an efficient ligand to promote copper-catalyzed domino reaction of ortho-iodo/bromo-anilines with β-keto esters/β-diketone for 2,3-disubstituted indoles' synthesis with high yields under mild conditions. The proto